Integration of published information into a resistance-associated mutation database for Mycobacterium tuberculosis

The Journal of Infectious Diseases
Hugh SalamonDavid L Dolinger

Abstract

Tuberculosis remains a major global public health challenge. Although incidence is decreasing, the proportion of drug-resistant cases is increasing. Technical and operational complexities prevent Mycobacterium tuberculosis drug susceptibility phenotyping in the vast majority of new and retreatment cases. The advent of molecular technologies provides an opportunity to obtain results rapidly as compared to phenotypic culture. However, correlations between genetic mutations and resistance to multiple drugs have not been systematically evaluated. Molecular testing of M. tuberculosis sampled from a typical patient continues to provide a partial picture of drug resistance. A database of phenotypic and genotypic testing results, especially where prospectively collected, could document statistically significant associations and may reveal new, predictive molecular patterns. We examine the feasibility of integrating existing molecular and phenotypic drug susceptibility data to identify associations observed across multiple studies and demonstrate potential for well-integrated M. tuberculosis mutation data to reveal actionable findings.

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Citations

Oct 23, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Kiatichai FaksriRick Twee-Hee Ong
Mar 15, 2015·The Journal of Infectious Diseases·Madhukar Pai, Marco Schito
Mar 17, 2017·Journal of Clinical Microbiology·Robyn S Lee, Madhukar Pai
Aug 1, 2018·Antimicrobial Agents and Chemotherapy·Tomasz JagielskiJarosław Dziadek
Oct 28, 2016·Nature Reviews. Disease Primers·Madhukar PaiMario Raviglione
May 8, 2016·Pharmaceutical Research·Michael A CollierKristy M Ainslie
Oct 21, 2016·Microbiology Spectrum·Madhukar PaiCatharina C Boehme

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