Integration of systemic and visceral sensory information by medullary catecholaminergic systems during peripheral inflammation

Annals of the New York Academy of Sciences
Jacob H HollisChristopher A Lowry

Abstract

The nucleus of the solitary tract (nTS) is topographically organized with respect to the distribution of afferent sensory innervation and efferent projection patterns. Evidence suggests that the cells within the nTS, including medullary catecholaminergic (CA) neurons, are functionally diverse and that during peripheral inflammation they are recruited in a topographically organized manner that reflects their associations with afferent sensory systems. It is therefore feasible that topographically organized subdivisions of the nTS and the medullary CA neurons contained within them are differentially involved in signaling systemic (e.g., derived from blood-borne signals) versus visceral sensory information (e.g., derived from afferent sensory signals within the vagus nerve) during peripheral inflammation. The purpose of this review is to summarize (1) the topographic organization of afferent sensory input from vagal and systemic signaling pathways to the nTS in relation to medullary CA neurons and (2) the functional evidence to support the differential involvement of topographically organized subpopulations of CA and non-CA neurons in relaying signals of visceral versus systemic sensory information.

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Citations

Dec 26, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Takao Mukuda, Masaaki Ando
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Haeman JangRichard J Smeyne
Sep 16, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Michael C Andresen, James H Peters
Oct 22, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Linda Rinaman
Nov 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ran Ji CuiSuzanne M Appleyard
Mar 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ran Ji CuiSuzanne M Appleyard
Dec 3, 2014·Best Practice & Research. Clinical Gastroenterology·Gerald Holtmann, Nicholas J Talley
Jul 30, 2009·Physiology & Behavior·Esther L SabbanLidia I Serova
Dec 20, 2007·The Journal of Pain : Official Journal of the American Pain Society·C Richard ChapmanChan Woo Song
Jan 6, 2009·Annals of the New York Academy of Sciences·Zdenko PirnikBoris Mravec
Apr 7, 2011·Journal of Neurochemistry·Florian GackièreCaroline Strube
Jun 18, 2015·Journal of Neurochemistry·Keodavanh ChounlamountryCaroline Strube
May 25, 2015·Brain, Behavior, and Immunity·Jan-Sebastian Grigoleit, Manfred Schedlowski
May 28, 2013·General and Comparative Endocrinology·Shigenori NobataYoshio Takei
Oct 26, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stephen J PageSuzanne M Appleyard

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