PMID: 9530667Apr 8, 1998Paper

Integration properties of bone substitute materials. Experimental studies on animals

Der Orthopäde
K P GüntherW Puhl

Abstract

In order to avoid the potential risks of disease transmission in allograft surgery, numerous substitute materials have been described. As the biological response to implant materials is different, we undertook the following study to assess type and amount of bone ingrowth in CaP-ceramics. 105 cylindrical bone defects with a diameter of 5.4 mm were created surgically in the femoral condyles of 53 skeletal mature NZW rabbits. The defects were filled with crushed coralline hydroxyapatite (HA) implants (n = 21), synthetically produced hydroxyapatite (n = 21) and surface-modified alpha-Tricalciumphosphate (TCP) grains (n = 21). 21 defects were left empty and other drill holes were filled with rabbit cancellous bone cylinders (n = 21) after 3 months of cryopreservation at -78 degrees C without sterilization. Following observation periods of 2, 4, 6, 8, 12, 26 and 52 weeks the femoral condyles were harvested for histological evaluation and quantitative analysis of bone ingrowth. Woven bone formation at implant periphery can be observed in all substances as early as 2 weeks postoperatively. At 4-week-intervals cryopreserved allografts show new bone apposition on surfaces of necrotic trabeculae and graft-host junctions by a predominantl...Continue Reading

Citations

Oct 14, 2004·Mund-, Kiefer- und Gesichtschirurgie : MKG·K-O HenkelV Bienengräber
Aug 14, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Henriette BretschneiderChristine Hofbauer
Mar 16, 2002·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·W BaerH D Carl
Oct 21, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Kai-Olaf HenkelVolker Bienengräber
Jul 10, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Karl Andreas SchlegelEndre Felszeghy

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