Integrative analyses of biomarkers and pathways for adipose tissue after bariatric surgery.

Adipocyte
Yingshan LiuLingling Xu

Abstract

We explored potential biomarkers and molecular mechanisms regarding multiple benefits after bariatric surgery. Differentially expressed genes (DEGs) for subcutaneous adipose tissue (AT) after bariatric surgery were identified by analyzing two expression profiles from the GEO. Subsequently, enrichment analysis, GSEA, PPI network, and gene-microRNAs and gene-TFs networks were interrogated to identify hub genes and associated pathways. Co-expressed DEGs included one that was up-regulated and 22 that were down-regulated genes. The enrichment analyses indicated that down-regulated DEGs were significantly involved in inflammatory responses. GSEA provided comprehensive evidence that most genes enriched in pro-inflammation pathways, while gene-sets after surgery enriched in metabolism. We identified nine hub genes in the PPI network, most of which were validated as highly expressed and hypomethylated in obesity by Attie Lab Diabetes and DiseaseMeth databases, respectively. DGIdb was also applied to predict potential therapeutic agents that might reverse abnormally high hub gene expression. Bariatric surgery induces a significant shift from an obese pro-inflammatory state to an anti-inflammatory state, with improvement in adipocyte meta...Continue Reading

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Datasets Mentioned

BETA
GSE59034
GSE29409

Methods Mentioned

BETA
pharmacotherapy
gastric bypass

Software Mentioned

Cytoscape
Pheatmap
Perl script
Affymetrix
STRING
MCODE ( Molecular Complex Detection )
Digest
CluePledia
R
clusterProiler

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