Integrative analyses of genetic variation in enzyme activities of primary carbohydrate metabolism reveal distinct modes of regulation in Arabidopsis thaliana.

Genome Biology
Joost J B KeurentjesDick Vreugdenhil

Abstract

Plant primary carbohydrate metabolism is complex and flexible, and is regulated at many levels. Changes of transcript levels do not always lead to changes in enzyme activities, and these do not always affect metabolite levels and fluxes. To analyze interactions between these three levels of function, we have performed parallel genetic analyses of 15 enzyme activities involved in primary carbohydrate metabolism, transcript levels for their encoding structural genes, and a set of relevant metabolites. Quantitative analyses of each trait were performed in the Arabidopsis thaliana Ler x Cvi recombinant inbred line (RIL) population and subjected to correlation and quantitative trait locus (QTL) analysis. Traits affecting primary metabolism were often correlated, possibly due to developmental control affecting multiple genes, enzymes, or metabolites. Moreover, the activity QTLs of several enzymes co-localized with the expression QTLs (eQTLs) of their structural genes, or with metabolite accumulation QTLs of their substrates or products. In addition, many trait-specific QTLs were identified, revealing that there is also specific regulation of individual metabolic traits. Regulation of enzyme activities often occurred through multiple ...Continue Reading

References

Aug 1, 1997·Current Opinion in Lipidology·Y C ChagnonC Bouchard
Dec 29, 2000·Nature·UNKNOWN Arabidopsis Genome Initiative
Feb 13, 2001·Current Opinion in Biotechnology·O FiehnT Altmann
Jan 17, 2002·Functional & Integrative Genomics·R A Martienssen
Jan 1, 2003·Journal of Experimental Botany·Nigel G HalfordYuhua Zhang
Jan 17, 2003·Plant Physiology·Olivier LoudetFrançoise Daniel-Vedele
Feb 13, 2003·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·L. RauhS. Buckler
May 16, 2003·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·L BentsinkD Vreugdenhil
Jul 10, 2003·Current Opinion in Biotechnology·Ernst Ludwig Winnacker
Sep 2, 2003·Metabolic Engineering·Fernando CarrariAlisdair R Fernie
Sep 16, 2003·EMBO Reports·Ewa Urbanczyk-WochniakAlisdair R Fernie
Jun 1, 1996·Annual Review of Plant Physiology and Plant Molecular Biology·Steven C. Huber, Joan L. Huber
Jul 22, 2004·Nature Reviews. Genetics·Orjan Carlborg, Chris S Haley
Sep 21, 2004·Annual Review of Plant Biology·Maarten KoornneefDick Vreugdenhil
Jan 26, 2005·Biochemical Society Transactions·N AvonceG Iturriaga
Jul 12, 2005·Nature·Josette MasleGraham D Farquhar
Feb 8, 2006·Journal of Plant Research·Silvia GonzaliPierdomenico Perata
Feb 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lidiya I SergeevaDick Vreugdenhil
May 4, 2006·Annual Review of Plant Biology·Rita ZrennerRalf Boldt
Jun 6, 2006·Nature Genetics·Joost J B KeurentjesMaarten Koornneef

❮ Previous
Next ❯

Citations

Oct 14, 2011·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Jianyi ZhaoJinling Meng
Dec 6, 2011·Journal of Experimental Botany·R Kooke, J J B Keurentjes
Mar 26, 2010·Plant Physiology·Marie-Caroline SteinhauserMark Stitt
Oct 21, 2010·Plant Physiology·Barbara EgliSebastian Streb
Jul 4, 2009·The Plant Cell·Carlos Alonso-BlancoMaarten Koornneef
Nov 17, 2010·PLoS Genetics·Eva K F ChanDaniel J Kliebenstein
Dec 18, 2013·Trends in Plant Science·Mark Stitt, Yves Gibon
Apr 20, 2010·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·R Harel-BejaN Katzir
Jan 21, 2009·Annual Review of Plant Biology·Kazuki Saito, Fumio Matsuda
Jul 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Dapeng LiEmmanuel Gaquerel
Oct 23, 2012·Trends in Genetics : TIG·Natalia Carreno-QuinteroJoost J B Keurentjes
Jan 11, 2011·Trends in Plant Science·Joost J B KeurentjesBart P H J Thomma
Jan 24, 2009·Current Opinion in Plant Biology·Joost J B Keurentjes
Nov 26, 2008·Trends in Genetics : TIG·Alisdair R Fernie, Nicolas Schauer
Nov 6, 2009·Molecular Systems Biology·Maria PiquesMark Stitt
May 14, 2011·Molecular Ecology Resources·Mirka MacelJoost J B Keurentjes
Apr 23, 2010·The Plant Journal : for Cell and Molecular Biology·Mark StittBjörn Usadel
Jun 16, 2015·Frontiers in Plant Science·Mariana Sotelo-SilveiraStefan de Folter
Jan 27, 2015·Annual Review of Plant Biology·Ronan Sulpice, Peter C McKeown
Apr 16, 2013·Current Biology : CB·Fabien ChardonAnne Krapp
Jan 13, 2015·Molecular Plant·Miyako KusanoKazuki Saito
Jul 9, 2016·Plant & Cell Physiology·Mohammad R GhaffariMohammad R Hajirezaei
Aug 9, 2016·Annual Review of Cell and Developmental Biology·Takehiko Ogura, Wolfgang Busch
Dec 21, 2016·The Plant Journal : for Cell and Molecular Biology·Harm NijveenBasten L Snoek
May 29, 2014·Molecular & Cellular Proteomics : MCP·Stéphanie ArrivaultWaltraud X Schulze
Nov 7, 2017·Metabolomics : Official Journal of the Metabolomic Society·Rashid H KazmiHenk W M Hilhorst
May 24, 2020·The Plant Journal : for Cell and Molecular Biology·Min DengYingjie Xiao
Jun 20, 2013·Plant, Cell & Environment·Joost J B KeurentjesBas J Zwaan

❮ Previous
Next ❯

Software Mentioned

Excel
SPSS
MapQTL
EPISTAT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Plant Biology
Joost J B Keurentjes
Proceedings of the National Academy of Sciences of the United States of America
Ronan SulpiceMark Stitt
Nature Genetics
Joost J B KeurentjesMaarten Koornneef
© 2022 Meta ULC. All rights reserved