Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile

Journal of Dermatological Science
Deng-Feng ZhangYong-Gang Yao

Abstract

Leprosy is an ancient chronic infection in the skin and peripheral nerves caused by Mycobacterium leprae. The development of leprosy depends on genetic background and the immune status of the host. However, there is no systematic view focusing on the biological pathways, interaction networks and overall expression pattern of leprosy-related immune and genetic factors. To identify the hub genes in the center of leprosy genetic network and to provide an insight into immune and genetic factors contributing to leprosy. We retrieved all reported leprosy-related genes and performed integrative analyses covering gene expression profiling, pathway analysis, protein-protein interaction network, and evolutionary analyses. A list of 123 differentially expressed leprosy related genes, which were enriched in activation and regulation of immune response, was obtained in our analyses. Cross-disorder analysis showed that the list of leprosy susceptibility genes was largely shared by typical autoimmune diseases such as lupus erythematosus and arthritis, suggesting that similar pathways might be affected in leprosy and autoimmune diseases. Protein-protein interaction (PPI) and positive selection analyses revealed a co-evolution network of lepros...Continue Reading

References

Jan 23, 2004·Nature·Marcelo T MiraErwin Schurr
Aug 2, 2006·QJM : Monthly Journal of the Association of Physicians·S K Cohn, L T Weaver
Aug 23, 2006·Human Molecular Genetics·Kerrie ToshRamasamy Pitchappan
Jul 12, 2007·Genome Research·Laura Gómez-ValeroFrancisco J Silva
Jan 8, 2008·The Journal of Infectious Diseases·Pierre-Yves BochudAlan Aderem
Dec 2, 2008·FEMS Immunology and Medical Microbiology·Om Parkash
Dec 9, 2008·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Danilo Santana Alessio FranceschiJeane Eliete Laguila Visentainer
Nov 3, 2009·Nature Genetics·Marc MonotStewart T Cole
Dec 19, 2009·The New England Journal of Medicine·Fu-Ren ZhangJian-Jun Liu
Jan 12, 2010·Current Opinion in Immunology·Robert L Modlin
Mar 31, 2010·The Journal of Infectious Diseases·William Richard BerringtonThomas Richard Hawn
Jul 10, 2010·PLoS Pathogens·Sunny H WongFredrik O Vannberg
Dec 2, 2010·Microbiology and Molecular Biology Reviews : MMBR·Elizabeth A MischThomas R Hawn
Jan 31, 2012·Nature Medicine·Philip T LiuRobert L Modlin
Mar 31, 2012·The Journal of Infectious Diseases·Ana Lucia M SousaMariane M A Stefani
Jul 4, 2012·Genomics·C George Priya DossChakraborty Chiranjib
Jan 11, 2013·Memórias do Instituto Oswaldo Cruz·M Patricia Joyce
Feb 19, 2013·Cell·Sharon R GrossmanPardis C Sabeti
Jul 13, 2013·Nature Reviews. Immunology·Petr Broz, Denise M Monack
Jul 23, 2013·Actas dermo-sifiliográficas·K EichelmannJ Ocampo-Candiani
Oct 8, 2013·PLoS Neglected Tropical Diseases·Carlijn G N Voorend, Erik B Post
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Pushpendra SinghStewart T Cole
Sep 12, 2015·Journal of Dermatological Science·Yang-Lin XiangYong-Gang Yao

❮ Previous
Next ❯

Citations

Oct 23, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Dong WangYong-Gang Yao
Oct 8, 2016·Journal of Dermatological Science·Guo-Dong LiYong-Gang Yao
May 3, 2018·Nature Communications·Ben Krause-KyoraAlmut Nebel
Mar 2, 2021·Clinical Genetics·Deng-Feng ZhangYong-Gang Yao
May 1, 2018·American Journal of Human Genetics·Dong WangYong-Gang Yao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Current Opinion in Immunology
Alexandre AlcaïsLaurent Abel
Acta Pathologica Et Microbiologica Scandinavica. Section B: Microbiology and Immunology
B MyrvangD R Samuel
© 2021 Meta ULC. All rights reserved