Abstract
The development of human cancer is a highly complex process and can be considered the result of several combined events, such as genetic alterations, disturbance of signal transduction, or failure of immunological surveillance. Cancer-related databases usually focus on specific fields of research, e.g., cancer genetics or cancer immunology, whereas the complexity of cancer genesis requires an integrated analysis of heterogeneous data from several sources. Here we present the cancer-associated protein database (CAP), a novel analysis system for cancer-related data. CAP integrates data from multiple external databases, augments these data with functional annotations, and offers tools for statistical analysis of these data. We have employed CAP to analyze genes that have been found to cause an autoimmune response in cancer. In particular, we explored the connection between the autoimmune response, mutations, and overexpression of these genes. Our preliminary results suggest that mutations are not significant contributors to raising an antibody response against tumor antigens, whereas overexpression seems to play a more important role. We hereby demonstrate how different types of data can be integrated and analyzed successfully, pr...Continue Reading
References
Dec 1, 1992·Genomics·K Nakai, M Kanehisa
Nov 1, 1995·Gut·J A MartinezM L Lacombe
Jan 1, 1997·Human Molecular Genetics·N BrassE Meese
Aug 1, 1997·Molecular Medicine Today·O TüreciM Pfreundschuh
Aug 8, 1998·Bioinformatics·K H CheungD G Shin
Nov 13, 1998·Human Molecular Genetics·D HeckelE Meese
Jun 17, 1999·International Journal of Cancer. Journal International Du Cancer·L ChengQ Wei
Nov 2, 1999·Biochemical and Biophysical Research Communications·T ShimizuJ Nishihira
Feb 29, 2000·Clinical Biochemistry·K AngelopoulouE P Diamandis
Mar 4, 2000·Nature Genetics·D T RossP O Brown
Dec 2, 2000·Journal of the American Academy of Dermatology·R HenriqueC Jerónimo
Jan 11, 2000·Nucleic Acids Research·K D Pruitt, D R Maglott
Jun 26, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·M D Whitaker
Jul 21, 2001·Oncogene·A K StrussE Meese
Aug 29, 2001·Bioinformatics·S Hua, Z Sun
Sep 11, 2001·Cancer·C BauerE U Meese
Nov 13, 2001·Clinical and Experimental Immunology·U FischerE Meese
Jan 17, 2002·Genes, Chromosomes & Cancer·Eckart Meese, Nicole Comtesse
Jan 23, 2002·Oncogene·Nicole ComtesseEckart Meese
Jun 25, 2002·Journal of Molecular Biology·L J JensenS Brunak
Sep 5, 2002·Cancer·Carole HazanDavid Polsky
Sep 13, 2002·BMC Bioinformatics·Pierre Dönnes, Arne Elofsson
Oct 29, 2002·International Journal of Cancer. Journal International Du Cancer·Isabel DiesingerEckart Meese
Nov 21, 2002·Protein Science : a Publication of the Protein Society·Rajesh Nair, Burkhard Rost
Jan 10, 2003·Nucleic Acids Research·Brigitte BoeckmannMichel Schneider
Mar 26, 2003·Bioinformatics·L J JensenS Brunak
Jul 31, 2003·Mutation Research·Katja Mitrunen, Ari Hirvonen
Apr 16, 2004·Nature·Steve Buckingham