Integrative analysis reveals enhanced regulatory effects of human long intergenic non-coding RNAs in lung adenocarcinoma

Journal of Genetics and Genomics = Yi Chuan Xue Bao
You ZhouXiangyin Kong

Abstract

Although there is an accumulating appreciation of the key roles that long intergenic non-coding RNAs (lincRNAs) play in diverse cellular processes, our knowledge of how lincRNAs function in cancer remains sparse. Here, we present a comprehensive landscape of RNA-seq transcriptome profiles of lung adenocarcinomas and their paired normal counterparts to unravel gene regulation rules of lincRNAs. Consistent with previous findings of co-expression between neighboring protein-coding genes, lincRNAs were typically co-expressed with their neighboring genes, which was found in both cancerous and normal tissues. By building a mathematical model based on correlated gene expression, we distinguished an additional subset of lincRNAs termed "regulatory lincRNAs", representing their dominant roles in gene regulation. The number of regulatory lincRNAs was significantly higher in cancerous compared to normal tissues, and most of them positively regulated protein-coding genes in trans. Functional validation, using knockdown, determined that regulatory lincRNA, GAS5, affected its predicted protein-coding targets. Moreover, we discovered hundreds of differentially expressed regulatory lincRNAs with inclusion of some cancer-associated lincRNAs. Ou...Continue Reading

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Citations

Mar 5, 2016·Biology of Reproduction·Maoliang RanZhaohui Li
Jun 30, 2018·International Journal of Molecular Sciences·Marta MajewskaMariusz Krzysztof Majewski
Mar 3, 2020·Frontiers in Bioengineering and Biotechnology·Hao ZhangBin Zhang
Jul 3, 2021·International Journal of Molecular Sciences·Elena A FilippovaEleonora A Braga

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