Integrative assessment of enantioselectivity in endocrine disruption and immunotoxicity of synthetic pyrethroids

Environmental Pollution
Meirong ZhaoWeiping Liu

Abstract

The increasing release of chiral chemicals into the environment dictates attention to a better understanding of enantioselectivity in their human and ecotoxicological effects. Although enantioselectivity has been considered in many recent studies, there is little effort for discerning the connection between different processes, and as such, our current knowledge about chiral contaminants is rather scattered and incoherent. In this study, we simultaneously evaluated enantioselectivity of two chiral pesticides, lambda-cyhalothrin (LCT) and (Z)-cis-bifenthrin (cis-BF), in immunotoxicity to macrophage cells (RAW264.7), and endocrine disruption activity in human breast carcinoma cell line MCF-7. Analysis of cell proliferation, cell viability, apoptosis, and receptor gene expression showed significant differences between the enantiomers of LCT or cis-BF in estrogenic potential and immunocytotoxicity. The selectivity in these effects consistently followed the same direction, with (-)-LCT or 1S-cis-BF displaying a greater activity than its counterpart. The consistency was attributed to interplaying mechanisms in the closely interacting immune and endocrine systems. The underlying interplays suggest that other chiral xenobiotics may als...Continue Reading

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Citations

Sep 1, 2012·PloS One·Meirong ZhaoWeiping Liu
Feb 3, 2016·International Archives of Occupational and Environmental Health·Mylène RatelleMichèle Bouchard
Jun 21, 2015·The Science of the Total Environment·Xiaoli ShenFangxing Yang
Feb 28, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Anne-Marie SaillenfaitJean-Philippe Sabaté
Sep 26, 2012·Environmental Toxicology and Chemistry·Susanne M BranderGary N Cherr
Mar 19, 2016·Environmental Science and Pollution Research International·Ines DhouibMohamed Montassar Lasram
Jan 23, 2014·Environmental Toxicology·Yuanxiang JinZhengwei Fu
Aug 26, 2014·Pesticide Biochemistry and Physiology·Yuanxiang JinZhengwei Fu
Dec 17, 2014·Toxicology Letters·Mylène RatelleMichèle Bouchard
Jul 28, 2016·Environmental Science & Technology·Susanne M BranderDaniel Schlenk
Dec 30, 2017·Journal of Exposure Science & Environmental Epidemiology·Jonathan Côté, Michèle Bouchard
Dec 15, 2011·Journal of Environmental Monitoring : JEM·Quan ZhangMeirong Zhao
Jan 1, 2021·Talanta·Herbert Musarurwa, Nikita Tawanda Tavengwa
Feb 3, 2015·Chemical Research in Toxicology·Jing YeWeiping Liu

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