Integrative computational models of cardiac arrhythmias -- simulating the structurally realistic heart.

Drug Discovery Today. Disease Models
Natalia A Trayanova, Brock M Tice

Abstract

Simulation of cardiac electrical function, and specifically, simulation aimed at understanding the mechanisms of cardiac rhythm disorders, represents an example of a successful integrative multiscale modeling approach, uncovering emergent behavior at the successive scales in the hierarchy of structural complexity. The goal of this article is to present a review of the integrative multiscale models of realistic ventricular structure used in the quest to understand and treat ventricular arrhythmias. It concludes with the new advances in image-based modeling of the heart and the promise it holds for the development of individualized models of ventricular function in health and disease.

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Citations

Sep 29, 2011·Science Signaling·Kevin D CostaUri Hershberg
Feb 27, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jose M FerreroLucia Romero
May 7, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Bradley J Roth
Nov 15, 2016·Clinical Medicine Insights. Cardiology·Thomas V KarathanosNatalia A Trayanova

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