Integrative meta-analysis identifies microRNA-regulated networks in infantile hemangioma

BMC Medical Genetics
Natália BertoniPatricia P Reis

Abstract

Hemangioma is a common benign tumor in the childhood; however our knowledge about the molecular mechanisms of hemangioma development and progression are still limited. Currently, microRNAs (miRNAs) have been shown as gene expression regulators with an important role in disease pathogenesis. Our goals were to identify miRNA-mRNA expression networks associated with infantile hemangioma. We performed a meta-analysis of previously published gene expression datasets including 98 hemangioma samples. Deregulated genes were further used to identify microRNAs as potential regulators of gene expression in infantile hemangioma. Data were integrated using bioinformatics methods, and genes were mapped in proteins, which were then used to construct protein-protein interaction networks. Deregulated genes play roles in cell growth and differentiation, cell signaling, angiogenesis and vasculogenesis. Regulatory networks identified included microRNAs miR-9, miR-939 and let-7 family; these microRNAs showed the most number of interactions with deregulated genes in infantile hemangioma, suggesting that they may have an important role in the molecular mechanisms of disease. Additionally, results were used to identify drug-gene interactions and drugg...Continue Reading

References

Jun 1, 1994·The Journal of Clinical Investigation·K TakahashiR A Ezekowitz
Sep 22, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·M VikkulaJ B Mulliken
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Matthew R RitterMartin Friedlander
Jul 23, 2003·Archives of Dermatology·Milton WanerMartin C Mihm
Dec 19, 2003·Nucleic Acids Research·Sam Griffiths-Jones
May 15, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Soheil S DadrasMichael Detmar
Jun 24, 2004·Nature Reviews. Genetics·Lin He, Gregory J Hannon
Jul 3, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·J-C Tille, M S Pepper
Jun 28, 2005·Current Opinion in Genetics & Development·Brian D Harfe
Dec 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Carmen M BarnésSteven J Fishman
Dec 31, 2005·Nucleic Acids Research·Sam Griffiths-JonesAnton J Enright
Jul 19, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Gianpiero Di LevaCarlo M Croce
Oct 10, 2006·Oncogene·J M Cummins, V E Velculescu
Nov 10, 2007·The Journal of Biological Chemistry·Lisa B FrankelAnders H Lund
Apr 23, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Scott D Boyd
Jun 14, 2008·The New England Journal of Medicine·Christine Léauté-LabrèzeAlain Taïeb
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Aug 5, 2008·Pediatrics·Linda C ChangUNKNOWN Hemangioma Investigator Group
Sep 5, 2008·PLoS Medicine·Adaikalavan RamasamyDouglas G Altman
Jan 8, 2009·Science Signaling·Jason E Fish, Deepak Srivastava
May 12, 2009·Angiogenesis·Elisa Boscolo, Joyce Bischoff
Feb 23, 2010·Nature Cell Biology·Li MaRobert A Weinberg
Oct 5, 2010·Pediatric Clinics of North America·Kristen E Holland, Beth A Drolet
Nov 3, 2010·Nucleic Acids Research·Ana Kozomara, Sam Griffiths-Jones
Jul 27, 2011·Pediatrics·Marcia HogelingOrli Wargon
Feb 22, 2012·EMBO Molecular Medicine·Marilena V Iorio, Carlo M Croce
Mar 27, 2012·Journal of Clinical Pathology·Tinte ItinteangDarren J Day
Nov 8, 2012·Nature Methods·Rintaro SaitoTrey Ideker
Dec 4, 2012·Nucleic Acids Research·Andrea FranceschiniLars J Jensen
Feb 22, 2013·Molecular Cancer Therapeutics·Sivapriya PonnurangamDharmalingam Subramaniam

❮ Previous
Next ❯

Citations

Oct 12, 2017·Pediatric Research·Lei ChangXiaoxi Lin
Dec 23, 2017·International Journal of Immunopathology and Pharmacology·Yang WangJing-Min Ou
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Yaping JiangYihui Chen

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Software Mentioned

Biological Networks Gene Ontology ( BiNGO )
PubChem
Metasearch STRING
mirDIP
Cytoscape
BiNGO
Ensembl
STRING

Related Concepts