Integrative pharmacology and drug discovery--is the tide finally turning?

Nature Reviews. Drug Discovery
Michael C Collis

Abstract

In vivo animal experiments are essential (and a regulatory requirement) to demonstrate the potential efficacy, safety and pharmacodynamic/pharmacokinetic profile of candidate drugs. However, the number of pharmacologists (and other bioscientists) with integrative (in vivo) pharmacology skills has been in decline for a number of years, as have the opportunities for students to learn such skills. This article reviews some recent initiatives that are underway to rebuild this essential skills base in the United Kingdom and the United States. Partnerships between industry and national funders of research and education have proved to be a particularly effective approach to support this strategically important area of biological science.

References

Jan 24, 2002·Trends in Pharmacological Sciences·UNKNOWN In Vivo Pharmacology Training Group
Jun 7, 2003·Nature Reviews. Drug Discovery·Simon Frantz
Aug 3, 2004·Nature Reviews. Drug Discovery·Ismail Kola, John Landis

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Citations

Aug 9, 2011·Journal of Pharmacological and Toxicological Methods·Aileen J F KingIan M Kinchin
Apr 21, 2007·The International Journal of Biochemistry & Cell Biology·Meena Kishore SakharkarShazib Pervaiz
May 20, 2008·Biochemical Pharmacology·S J EnnaM Williams
Jun 15, 2016·Indian Journal of Pharmacology·David I Lewis

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