Integrative Physiology of Pneumonia

Physiological Reviews
Lee J QuintonJoseph P Mizgerd

Abstract

Pneumonia is a type of acute lower respiratory infection that is common and severe. The outcome of lower respiratory infection is determined by the degrees to which immunity is protective and inflammation is damaging. Intercellular and interorgan signaling networks coordinate these actions to fight infection and protect the tissue. Cells residing in the lung initiate and steer these responses, with additional immunity effectors recruited from the bloodstream. Responses of extrapulmonary tissues, including the liver, bone marrow, and others, are essential to resistance and resilience. Responses in the lung and extrapulmonary organs can also be counterproductive and drive acute and chronic comorbidities after respiratory infection. This review discusses cell-specific and organ-specific roles in the integrated physiological response to acute lung infection, and the mechanisms by which intercellular and interorgan signaling contribute to host defense and healthy respiratory physiology or to acute lung injury, chronic pulmonary disease, and adverse extrapulmonary sequelae. Pneumonia should no longer be perceived as simply an acute infection of the lung. Pneumonia susceptibility reflects ongoing and poorly understood chronic conditio...Continue Reading

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Citations

Aug 1, 2018·American Journal of Respiratory and Critical Care Medicine·Lee J Quinton
Jun 5, 2019·Infection and Immunity·Yuri KimLee J Quinton
Aug 16, 2019·PloS One·Katrina E TraberLee J Quinton
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Aug 29, 2019·American Journal of Respiratory and Critical Care Medicine·Stavros Garantziotis, Sadis Matalon
Mar 10, 2020·American Journal of Respiratory and Critical Care Medicine·Matthew W SemlerLora A Reineck
Dec 14, 2018·American Journal of Respiratory and Critical Care Medicine·Samir GautamCharles S Dela Cruz
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Jan 29, 2020·JCI Insight·Antoine GuillonJoseph P Mizgerd
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Nov 1, 2020·International Journal of Molecular Sciences·Jaroslav Hrenak, Fedor Simko
Jan 10, 2021·Cellular & Molecular Immunology·Anukul T Shenoy, Joseph P Mizgerd
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Datasets Mentioned

BETA
GM120060

Methods Mentioned

BETA
bronchoalveolar lavage
lavage
GTPases
transgenic
targeted mutation

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