Integrative properties of radial oblique dendrites in hippocampal CA1 pyramidal neurons.

Neuron
Attila Losonczy, Jeffrey C Magee

Abstract

Although radial oblique dendrites are a major synaptic input site in CA1 pyramidal neurons, little is known about their integrative properties. We have used multisite two-photon glutamate uncaging to deliver different spatiotemporal input patterns to single branches while simultaneously recording the uncaging-evoked excitatory postsynaptic potentials and local Ca2+ signals. Asynchronous input patterns sum linearly in spite of the spatial clustering and produce Ca2+ signals that are mediated by NMDA receptors (NMDARs). Appropriately timed and sized input patterns ( approximately 20 inputs within approximately 6 ms) produce a supralinear summation due to the initiation of a dendritic spike. The Ca2+ signals associated with synchronous input were larger and mediated by influx through both NMDARs and voltage-gated Ca2+ channels (VGCCs). The oblique spike is a fast Na+ spike whose duration is shaped by the coincident activation of NMDAR, VGCCs, and transient K+ currents. Our results suggest that individual branches can function as single integrative compartments.

References

Sep 11, 1995·The Journal of Comparative Neurology·N J Bannister, A U Larkman
Jul 8, 1999·Current Opinion in Neurobiology·D JohnstonJ C Magee
Jul 19, 2002·Nature·Nace L GoldingNelson Spruston
Apr 3, 2003·Neuron·Panayiota PoiraziBartlett W Mel
Apr 3, 2003·Neuron·Panayiota PoiraziBartlett W Mel
Jul 10, 2003·Current Opinion in Neurobiology·Michael Häusser, Bartlett Mel
Oct 16, 2003·Brain Research. Molecular Brain Research·Carla Marchetti, Paola Gavazzo
Jan 20, 2004·Nature Neuroscience·Andreas FrickDaniel Johnston
May 25, 2004·Nature Neuroscience·Alon PolskyJackie Schiller
Aug 21, 2004·The Journal of Physiology·Knut HolthoffArthur Konnerth
Sep 15, 2004·Neuron·Vivien Chevaleyre, Pablo E Castillo
Dec 14, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sonia GaspariniJeffrey C Magee
Feb 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jun XuJian Kang
Jun 1, 2005·Current Opinion in Neurobiology·Jeffrey C Magee, Daniel Johnston
Jul 9, 2005·The Journal of Physiology·Nace L GoldingNelson Spruston

❮ Previous
Next ❯

Citations

Jul 4, 2006·Cell and Tissue Research·Knut HolthoffArthur Konnerth
Feb 15, 2008·Journal of Computational Neuroscience·K J KelleherK Josić
May 4, 2011·Journal of Computational Neuroscience·David Arthur StanleyWilliam L Ditto
Jul 7, 2011·ACS Chemical Neuroscience·Graham C R Ellis-Davies
Dec 22, 2007·Nature·Christopher D Harvey, Karel Svoboda
Jan 20, 2009·Nature·Leopoldo PetreanuKarel Svoboda
Jan 15, 2013·Nature Methods·Jonathan S MarvinLoren L Looger
Apr 25, 2008·Nature Neuroscience·Gaddum Duemani ReddyPeter Saggau
Jul 20, 2010·Nature Neuroscience·Attila LosonczyJeffrey C Magee
Jun 15, 2011·Nature Neuroscience·Joshua L PlotkinD James Surmeier
Jan 17, 2012·Nature Neuroscience·Matthew Lovett-BarronAttila Losonczy
Mar 1, 2012·Nature Neuroscience·Iris Oren, Dimitri M Kullmann
Oct 29, 2013·Nature Neuroscience·Benjamin Sivyer, Stephen R Williams
Jan 18, 2008·Nature Reviews. Neuroscience·Paul TiesingaTerrence J Sejnowski
Jun 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·David A MarkowitzDavid W Tank
Jul 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Quan WenDmitri B Chklovskii
Jun 1, 2010·Proceedings of the National Academy of Sciences of the United States of America·Raoul-Martin Memmesheimer
Dec 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jiang HaoXiao-hui Zhang
Nov 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Francesca AnselmiValentina Emiliani
Feb 26, 2009·Cerebral Cortex·Takuma KitanishiMaki K Yamada
Sep 29, 2011·Journal of Biomedical Optics·Giulietta PinatoDan Cojoc
Oct 17, 2009·Science·Viktor VargaTamás F Freund
Aug 14, 2010·Science·Tiago BrancoMichael Häusser
Jul 12, 2013·Annual Review of Neuroscience·Guy MajorJackie Schiller
Feb 7, 2007·Annual Review of Neuroscience·Veronica A Alvarez, Bernardo L Sabatini
Aug 31, 2012·Journal of Neurophysiology·Rishikesh Narayanan, Daniel Johnston
Apr 2, 2010·Journal of Neurophysiology·Francesco Savelli, James J Knierim
Oct 27, 2012·Journal of Neurophysiology·Francis LajeunesseIgor Timofeev
Feb 5, 2009·Neural Computation·Michael Krumin, Shy Shoham
Mar 27, 2010·Neural Computation·Yingxue Wang, Shih-Chii Liu
Sep 15, 2009·PLoS Computational Biology·Balázs UjfalussyPéter Erdi
Dec 29, 2010·PLoS Computational Biology·Eleftheria Kyriaki PissadakiPanayiota Poirazi
Jul 26, 2012·PLoS Computational Biology·Bardia F BehabadiBartlett W Mel
Jun 13, 2014·PLoS Computational Biology·Bruce BobierChris Eliasmith
May 21, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amanda FoustDavid A McCormick
Oct 24, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zayd M Khaliq, Bruce P Bean

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Sonia Gasparini, Jeffrey C Magee
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Sonia GaspariniJeffrey C Magee
© 2022 Meta ULC. All rights reserved