PMID: 9672118Jul 22, 1998

Integrative properties of the major pelvic ganglion in the rat

Journal of the Autonomic Nervous System
B FélixJ P Niel

Abstract

The integrative properties of the major pelvic ganglion were investigated in the male rat on an in vitro preparation consisting of the ganglion connected to the hypogastric, pelvic and cavernous nerves. The electrical activity of ganglionic neurones was recorded using intracellular recording techniques. The neurones never displayed any spontaneous activity and were found to be only of the phasic type. Fast synaptic activation could be evoked in the same neurone by stimulating the hypogastric, pelvic and cavernous nerves with a single pulse. This activation was not affected by hexamethonium plus D-tubocurarine but was abolished by mecamylamine. During nerve stimulation with a train of pulses, a gradual depression of the fast synaptic responses occurred. This phenomenon increased with the frequency of stimulation. Our results show that the neurones of the major pelvic ganglion can integrate central inputs from both the sympathetic and parasympathetic systems as well as peripheral inputs. This activation is modulated by a rate limiting mechanism. Thus the major pelvic ganglion should not be considered as a simple relay but as a true integrative nervous centre which opens new perspectives concerning its role in the nervous control ...Continue Reading

Citations

Jun 19, 2001·Progress in Neurobiology·P M DunnG Burnstock
Sep 21, 2002·Autonomic Neuroscience : Basic & Clinical·Andrei Yu Bobryshev, Vladimir I Skok
Jun 22, 2002·Gut·J H SzurszewskiS M Miller
Nov 6, 2009·Autonomic Neuroscience : Basic & Clinical·Yi-Fan LiJessica Freeling
Mar 16, 2007·Autonomic Neuroscience : Basic & Clinical·H TanM A Vizzard
Aug 7, 2013·Organogenesis·Jane E Eastham, James I Gillespie
Sep 2, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kenneth P WinnardKaren J Berkley

Related Concepts

Electric Stimulation Technique
Electrophysiology (Science)
Ganglia
Neurons
Pelvis
Perineurium
Reaction Time
Synapses
Rats, Holtzman
End Plate Potentials

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