Integrative spike dynamics of rat CA1 neurons: a multineuronal imaging study.

The Journal of Physiology
Takuya SasakiYuji Ikegaya

Abstract

The brain operates through a coordinated interplay of numerous neurons, yet little is known about the collective behaviour of individual neurons embedded in a huge network. We used large-scale optical recordings to address synaptic integration in hundreds of neurons. In hippocampal slice cultures bolus-loaded with Ca2+ fluorophores, we stimulated the Schaffer collaterals and monitored the aggregate presynaptic activity from the stratum radiatum and individual postsynaptic spikes from the CA1 stratum pyramidale. Single neurons responded to varying synaptic inputs with unreliable spikes, but at the population level, the networks stably output a linear sum of synaptic inputs. Nonetheless, the network activity, even though given constant stimuli, varied from trial to trial. This variation emerged through time-varying recruitment of different neuron subsets, which were shaped by correlated background noise. We also mapped the input-frequency preference in spiking activity and found that the majority of CA1 neurons fired in response to a limited range of presynaptic firing rates (20-40 Hz), acting like a band-pass filter, although a few neurons had high pass-like or low pass-like characteristics. This frequency selectivity depended o...Continue Reading

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Citations

May 4, 2010·Analytical and Bioanalytical Chemistry·Naoya TakahashiYuji Ikegaya
Dec 5, 2006·Nature Methods·Werner GöbelFritjof Helmchen
Jan 6, 2009·Biological & Pharmaceutical Bulletin·Shigehiro Namiki, Yuji Ikegaya
Apr 18, 2013·PLoS Computational Biology·Adam Ponzi, Jeffery R Wickens
Apr 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hajime TakanoDouglas A Coulter
Jan 7, 2009·The International Journal of Neuroscience·Shigehiro NamikiYuji Ikegaya
Nov 13, 2015·Journal of Neuroscience Methods·Agnieszka F SzymanskaZoran Nenadic
Apr 10, 2007·Neuroscience Research·Naoya TakahashiYuji Ikegaya
Sep 12, 2006·Current Opinion in Neurobiology·Peter Saggau
Aug 2, 2015·Neuroscience Letters·Xiaoqi Geng, Masahiro Mori
Jan 12, 2019·The European Journal of Neuroscience·Omar JáidarGordon William Arbuthnott
Jan 11, 2008·Journal of Neurophysiology·Luis Carrillo-ReidJosé Bargas
Sep 21, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Zhaohui LiXiaoli Li
Jun 16, 2019·Nature Communications·Khaled GhandourKaoru Inokuchi
Aug 27, 2021·PloS One·Daichi KonnoNobuyoshi Matsumoto

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