PMID: 1268768May 1, 1976

Integrative versus delay line characteristics of cerebellar cortex

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
W A MacKay, J T Murphy

Abstract

In order to determine which of two general models ("tapped delay line" or "integrator") provides a more accurate desciption of mammalian Purkinje cell (P-cell) activation by natural stimulation, the spatial and temporal characteristics of a population of neurons in cerebellar cortex responsive to small controlled stretches of forelimb muscles were examined in awake, locally anesthetized cats. Stretch of a single wrist muscle excited P-cells over a distance of about 1 mm in the long axis of a folium, a span which is at most half the length of parallel fibers. Both granule cells and molecular layer interneurons were excited over a wider zone than P-cells. Furthermore, P-cells across a response zone all fired on the average at the same time, as determined by computing peristimulus cross-interval histograms from pairs of simultaneously recorded neurons. Consistent delays could only be demonstrated in the minimal response latencies as measured from peristimulus time histograms. These delays, however, were longer than could be ascribed to parallel fiber conduction velocity. No evidence, therefore, was found in cat cerebellum to support the "tapped delay line" model, which postulates the successive activation of P-cells as an excitato...Continue Reading

References

Jul 1, 1971·Journal of Neurophysiology·R Llinás, C Nicholson
Aug 1, 1974·Physiology & Behavior·J T MurphyY C Wong
Nov 1, 1974·Journal of Neurophysiology·W A MacKay, J T Murphy
Dec 1, 1974·Canadian Journal of Physiology and Pharmacology·J CourvilleN Diakiw
Oct 29, 1972·Experimental Brain Research·J C EcclesH Táboríková
Aug 31, 1973·Experimental Brain Research·D M ArmstrongR F Schild
Jan 1, 1974·Journal of Neurophysiology·E MugnainiJ C Houk
Apr 1, 1972·The Journal of Physiology·A R Gardner-Medwin
Oct 25, 1971·Experimental Brain Research·J D CookeB Sjölund
Aug 19, 1969·Experimental Brain Research·W Precht, R Llinás
Nov 1, 1969·Journal of Neurophysiology·C C Bell, R J Grimm
May 1, 1971·Biophysical Journal·N H Sabah, J T Murphy

Citations

Aug 11, 2015·Frontiers in Systems Neuroscience·Jonathan D Groth, Mesut Sahin
Oct 31, 2002·The European Journal of Neuroscience·Constanze HofstötterPaul F M J Verschure
May 18, 2017·The Journal of Physiology·Yeechan Wu, Indira M Raman
Feb 23, 2008·Experimental Brain Research·M S ValleR E Poppele

Related Concepts

Functional Cerebral Localization
Felis catus
Cerebellar Cortex Structure
Electrophysiology (Science)
Interneurons
Meissner's Corpuscle
Neural Inhibition
Purkinje Cells
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