Integrative whole-brain neuroscience in larval zebrafish

Current Opinion in Neurobiology
Gilles C VanwalleghemEthan K Scott

Abstract

Due to their small size and transparency, zebrafish larvae are amenable to a range of fluorescence microscopy techniques. With the development of sensitive genetically encoded calcium indicators, this has extended to the whole-brain imaging of neural activity with cellular resolution. This technique has been used to study brain-wide population dynamics accompanying sensory processing and sensorimotor transformations, and has spurred the development of innovative closed-loop behavioral paradigms in which stimulus-response relationships can be studied. More recently, microscopes have been developed that allow whole-brain calcium imaging in freely swimming and behaving larvae. In this review, we highlight the technologies underlying whole-brain functional imaging in zebrafish, provide examples of the sensory and motor processes that have been studied with this technique, and discuss the need to merge data from whole-brain functional imaging studies with neurochemical and anatomical information to develop holistic models of functional neural circuits.

Citations

Nov 28, 2018·Bioinspiration & Biomimetics·Mohamad AlsalmanEva Kanso
Sep 17, 2018·Journal of Biochemistry·Yoshihiro Omori, Tetsuo Kon
May 29, 2020·SLAS Discovery·Davide RubbiniVincenzo Di Donato
Sep 18, 2020·BMC Biology·Lena ConstantinEthan K Scott
Apr 2, 2020·Frontiers in Neural Circuits·Mónica FolgueiraJulián Yáñez
Sep 20, 2020·Scientific Reports·Mohamad RimaElim Hong
Dec 2, 2020·Nature Communications·Itia A Favre-BulleEthan K Scott
Oct 28, 2020·The Journal of Experimental Biology·William A HaneyJames A Strother
Dec 4, 2020·Environmental Toxicology and Chemistry·Jennifer A FitzgeraldColette Vom Berg
Jun 30, 2018·Current Opinion in Neurobiology·Martha W Bagnall, David Schoppik
Nov 20, 2018·Current Biology : CB·Itia A Favre-BulleEthan K Scott
Mar 4, 2021·Current Biology : CB·Rebecca E PoulsenEthan K Scott
May 4, 2021·Frontiers in Cell and Developmental Biology·David M JamesJulia E Dallman
May 30, 2021·Translational Stroke Research·Weijie ChenPeiying Li
Aug 30, 2020·Current Opinion in Neurobiology·Matthew Lovett-Barron
Aug 3, 2021·Frontiers in Molecular Neuroscience·Laura Corradi, Alessandro Filosa
Mar 18, 2021·Annual Review of Neuroscience·Rainer W Friedrich, Adrian A Wanner
Jul 8, 2021·Nature Communications·Alexandro D Ramirez, Emre R F Aksay

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