Integrin α6 as an invasiveness marker for hepatitis B viral X-driven hepatocellular carcinoma

Cancer Biomarkers : Section a of Disease Markers
Yi Rang KimJin Woo Choi

Abstract

Hepatitis B virus (HBV) accounts for more than 60% of hepatocellular carcinoma (HCC) cases. However, there is limited information about the features of HBV-driven HCC that differentiate it from other types of HCC. The aim of this study is to find a gene specific to HBV-driven HCC and understand its role during tumorigenesis. The differences in gene expression patterns were analyzed among patients with hepatitis virus-unrelated liver cirrhosis, and hepatitis C virus- and HBV-driven HCC. Genes expressed only in HBV patients were compared to genes of transgenic mice expressing hepatitis B viral X gene. Integrin α6 was commonly overexpressed in both HBV-driven HCC patients and transgenic mice expressing viral X. This gene's activation induced overexpression of integrin α6, as well as formation of integrins α6β1 and α6β4, without changing the expression of non-integrin laminin receptors. Suppression of integrin α6 caused significant inhibition of tumor migration in vitro. This study found a significant association between HBV and integrin α6, which may be responsible for early migration and invasion of HCC. Thus, integrin α6 is a predictive marker for tumor recurrence and invasiveness of HBV-driven HCC.

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Citations

Dec 4, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Yun ZhangGuo-Kai Feng
Aug 11, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Guo-Kai FengMu-Sheng Zeng
Nov 30, 2019·Cellular Signalling·A Sainio, H Järveläinen
Jul 27, 2021·World Journal of Clinical Cases·Gulsum Ozlem Elpek

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