Integrin adhesion in brain assembly: From molecular structure to neuropsychiatric disorders.

The European Journal of Neuroscience
Fanny JaudonLorenzo A Cingolani

Abstract

Integrins are extracellular matrix receptors that mediate biochemical and mechanical bi-directional signals between the extracellular and intracellular environment of a cell thanks to allosteric conformational changes. In the brain, they are found in both neurons and glial cells, where they play essential roles in several aspects of brain development and function, such as cell migration, axon guidance, synaptogenesis, synaptic plasticity and neuro-inflammation. Although there are many successful examples of how regulating integrin adhesion and signaling can be used for therapeutic purposes, for example for halting tumor progression, this is not the case for the brain, where the growing evidence of the importance of integrins for brain pathophysiology has not translated yet into medical applications. Here, we review recent literature showing how alterations in integrin structure, expression and signaling may be involved in the etiology of autism spectrum disorder, epilepsy, schizophrenia, addiction, depression and Alzheimer's disease. We focus on common mechanisms and recurrent signaling pathways, trying to bridge studies on the genetics and molecular structure of integrins with those on synaptic physiology and brain pathology. ...Continue Reading

References

Apr 25, 1996·The New England Journal of Medicine·E J WeissP J Goldschmidt-Clermont
Dec 1, 1995·Molecular Immunology·M Szabo, B W McIntyre
Jan 13, 2000·Archives of General Psychiatry·L A Glantz, D A Lewis
Jul 13, 2000·Archives of General Psychiatry·T H McGlashan, R E Hoffman
Dec 28, 2002·American Journal of Alzheimer's Disease and Other Dementias·Rita MorettiAntonio Bava
May 13, 2003·Journal of Neurophysiology·Bin LinChristine M Gall
Mar 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gloria LeeHanna Ksiezak-Reding
Jul 9, 2004·Archives of General Psychiatry·Gerard SanacoraGraeme F Mason
Aug 5, 2004·European Journal of Human Genetics : EJHG·Lauren A WeissMark Abney
Dec 8, 2004·Matrix Biology : Journal of the International Society for Matrix Biology·Catherine Ekwa-EkokaLynn M Schnapp
Apr 29, 2005·Journal of Neurochemistry·Joie A Bernard-TrifiloChristine M Gall
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chi-Shing ChanRonald L Davis
Feb 2, 2006·Neurobiology of Aging·Sarah WrightIrene Griswold-Prenner
May 26, 2006·European Journal of Human Genetics : EJHG·Lauren A WeissJames S Sutcliffe
Oct 25, 2006·The Journal of Cell Biology·Eileen Puklin-FaucherViola Vogel
Oct 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhen HuangLouis F Reichardt
Jan 5, 2007·Annual Review of Immunology·Bing-Hao LuoTimothy A Springer
Jan 11, 2007·The Journal of Biological Chemistry·Donna J WebbAlan F Horwitz
Apr 20, 2007·Neurobiology of Aging·Qinwen WangRoger Anwyl
Jun 5, 2007·Genome Biology·Yoshikazu TakadaScott Simon
Sep 13, 2007·Learning & Memory·Chi-Shing ChanRonald L Davis
Sep 21, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laurent GrocPascale Chavis
Oct 12, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mindan K SfakianosAnthony J Koleske
Feb 8, 2008·Genes, Brain, and Behavior·D MuyllaertF Van Leuven
Mar 12, 2008·The Journal of Cell Biology·Grzegorz M WilczynskiLeszek Kaczmarek
Apr 4, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Anna K KählerOle A Andreassen
Apr 17, 2008·Nature Reviews. Genetics·Brett S Abrahams, Daniel H Geschwind

❮ Previous
Next ❯

Citations

Dec 2, 2020·Neurobiology of Disease·Carolyn E Keating, D Kacy Cullen
Feb 22, 2021·Journal of Cellular Physiology·Yao SongDingming Huang
Apr 5, 2021·Journal of Inorganic Biochemistry·Christos T ChasapisMassimiliano Peana
Jul 3, 2021·International Journal of Molecular Sciences·Benita WiatrakKazimierz Gąsiorowski
Jun 3, 2021·The European Journal of Neuroscience·Alexander DityatevMarkus Morawski
Oct 26, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Hee-Ju KangJae-Min Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Related Papers

Seminars in Cancer Biology
S E LaFlamme, K L Auer
Histology and Histopathology
Jens SchittenhelmBence Sipos
International Journal of Molecular Sciences
Aleksandra Ellert-MiklaszewskaBozena Kaminska
Journal of Thrombosis and Haemostasis : JTH
Feng YeM H Ginsberg
© 2022 Meta ULC. All rights reserved