PMID: 7523420Oct 1, 1994Paper

Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization

The Journal of Cell Biology
T J WickhamGlen R Nemerow

Abstract

Human adenovirus type 2 (Ad2) enters host cells by receptor-mediated endocytosis, an event mediated by the virus penton base binding to cell surface integrins alpha v beta 3 and alpha v beta 5. While both alpha v integrins promote virus internalization, alpha v beta 5 is involved in the subsequent event of membrane permeabilization. Cells transfected with the beta 5 or beta 3 subunit, expressing either alpha v beta 5 and alpha v beta 3, respectively, were capable of supporting Ad2 infection to varying degrees. In this case, cells expressing alpha v beta 5 were significantly more susceptible to Ad2-induced membrane permeabilization, as well as to Ad2 infection, than cells expressing alpha v beta 3. Adenovirus-mediated gene delivery was also more efficient in cells expressing alpha v beta 5. These results suggest that the interaction of alpha v beta 5 with Ad2 penton base facilitates the subsequent step of virus penetration into the cell. These studies provide evidence for the involvement of a cellular receptor in virus-mediated membrane permeabilization and suggest a novel biological role for integrin alpha v beta 5 in the infectious pathway of a human adenovirus.

References

Dec 1, 1979·Archives of Biochemistry and Biophysics·R A Farishian, J R Whittaker
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D T CurielM Cotten
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E WagnerM L Birnstiel
Jun 26, 1987·Journal of Chromatography·M Waris, P Halonen
Apr 22, 1986·Biochemistry·R BlumenthalI Pastan
May 1, 1993·American Journal of Respiratory Cell and Molecular Biology·S A MetteS M Albelda
Jul 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·J F Thiel, K O Smith

❮ Previous
Next ❯

Citations

Feb 11, 1999·Journal of Neuroscience Research·G M Smith, M I Romero
Dec 13, 1997·Molecular Neurobiology·P Horellou, J Mallet
Oct 15, 2009·Amino Acids·Manjula Kalia, Shahid Jameel
Nov 5, 2003·Advanced Drug Delivery Reviews·Lali K Medina-Kauwe
Jan 7, 2004·Advanced Drug Delivery Reviews·Wesley M SharmanCynthia M Allen
Aug 11, 2000·Transplantation Proceedings·N ShinozukaS Kyo
Jun 4, 1998·Thrombosis Research·K T Preissner, D Seiffert
Jun 22, 2002·Antiviral Research·Paul J HippenmeyerDavid W Griggs
Jan 16, 2003·Virus Research·Terry JacksonElizabeth Fry
Aug 16, 2000·Advanced Drug Delivery Reviews·S R WinnJ O Hollinger
Nov 24, 2001·Advanced Drug Delivery Reviews·H MizuguchiT Hayakawa
Jun 6, 2003·Advanced Drug Delivery Reviews·Gary R Whittaker
Mar 23, 2004·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Akimitsu NasunoYoshifusa Aizawa
Jan 18, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Nia TatsisHildegund C J Ertl
May 16, 2012·Nanoscale·Marisa L HovlidM G Finn
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y WangG M Edelman
Sep 19, 2001·Human Gene Therapy·V BiermannS Kochanek
Sep 25, 1999·Human Gene Therapy·J P WisniveskyR G Crystal
Feb 3, 2005·Human Gene Therapy·John J Rux, Roger M Burnett
Dec 14, 2011·Molecular Biology of the Cell·Nina RintanenVarpu Marjomäki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.