Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells

Virology
M V AgrezR D Barry

Abstract

Viral entry into host cells depends upon specific interactions between virus attachment proteins and cell surface receptors that enable virus binding and internalization of virus and/or the virus-receptor complex. We have recently reported that the ubiquitous cell surface molecule, decay-accelerating factor (DAF), is a major cell attachment receptor for Coxsackieviruses B1, B3, and B5. However, DAF permits only virus binding and not virus internalization, invoking the presence of secondary or accessory receptors. Among the known receptors for enteroviruses are members of the cell adhesion molecule family known as integrins. In the present study, we found that expression of the epithelial-restricted integrin, alpha v beta 6, on colonic epithelial cells significantly enhanced Coxsackievirus B1-mediated cell lysis. Importantly, the viral-mediated cell killing required the presence of the 11-amino-acid C-terminal cytoplasmic extension unique to the beta 6 subunit, providing the first evidence of regulation of viral infectivity by integrin cytoplasmic domains. These results indicate that alpha v beta 6 expression on intestinal epithelial cells critically affects Coxsackievirus B1 infectivity. This may be essential in the conversion ...Continue Reading

References

Sep 1, 1985·Journal of Virology·J E MapolesR L Crowell
Jul 1, 1993·The Journal of Clinical Investigation·J M BergelsonM E Hemler
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·R P TomkoL Philipson
Sep 1, 1993·Current Biology : CB·J M White

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Citations

Apr 16, 2005·Clinical Microbiology Reviews·Alain L Servin
Jun 15, 2004·Journal of Virology·Ciğdem H WilliamsGlyn Stanway
Mar 13, 2014·Medical Microbiology and Immunology·A KühnlA Henke
Jul 15, 2006·Journal of Neurocytology·Giri VenkatramanFrank L Margolis
Aug 11, 2000·Transplantation Proceedings·K Yamanouchi
Sep 29, 2001·Journal of Virological Methods·G FriskH Diderholm
Apr 3, 2008·Medicinal Research Reviews·Armando M De PalmaJohan Neyts
Apr 4, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Mi Zhou, Fan Li
Jun 21, 2006·Biochimica Et Biophysica Acta·Jan-Henrik MikeschBurkhard Brandt
Feb 1, 2014·Circulation Research·Sharon Israeli-RosenbergRobert S Ross
Aug 15, 2003·The Journal of Biological Chemistry·Xiaowu LiDaniel M Ramos
Jan 25, 2000·The Journal of General Virology·G SibbetM S Campo
May 17, 2000·The Journal of General Virology·J Schneider-Schaulies
Oct 13, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·K ArihiroY Yokosaki
Aug 10, 1999·Journal of Virology·D R ShafrenA Suhrbier
Oct 10, 1998·Journal of Virology·D R Shafren

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