Integrin-alphavbeta6, a putative receptor for foot-and-mouth disease virus, is constitutively expressed in ruminant airways

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Jeremy K BrownDavid D S Collie

Abstract

Evolved functions of integrin-alpha(v)beta(6) include roles in epithelial cell-extracellular matrix protein interactions and in the binding and activation of latent TGF-beta(1). Integrin-alpha(v)beta(6) is also exploited as a receptor by foot-and-mouth disease virus (FMDV) and may play a significant role in its transmission and pathogenesis. The ovine beta(6) integrin subunit was cloned and sequenced (EMBL accession no. AJ439062). Screening of normal ovine tissues by RT-PCR and immunocytochemistry confirmed that integrin-alphavbeta6 is restricted to sheep epithelial cells. Integrin-alphavbeta6 expression was detected in epithelia of the airways, oral cavity, gastrointestinal tract, kidney, sweat glands, hair follicle sheaths, and the epidermis of pedal coronary band (PB) but not of normal skin. Consistent with FMDV tropism, integrin-alphavbeta6 was detected within the basal layers of the stratified squamous epithelium of the oral mucosa and PB. In addition, integrin-alphavbeta6 appears to be constitutively expressed in the normal airways of both cattle and sheep. The latter finding suggests that ruminant airway epithelium presents a highly accessible target for initiation of infection with FMDV by inhalation.

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Citations

Apr 1, 2014·Nature Medicine·Emanuel RognoniReinhard Fässler
Sep 12, 2007·Veterinary Pathology·M Y GulbaharY B Kabak
Jul 16, 2010·The Journal of Pathology·Antonio SahaJohn F Marshall
Nov 30, 2018·Frontiers in Microbiology·Gisselle N MedinaTeresa de Los Santos
Jan 5, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Willemieke S TummersSanjiv S Gambhir
Feb 6, 2021·Veterinary Microbiology·Zhidong ZhangYanmin Li

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Datasets Mentioned

BETA
AF115476

Methods Mentioned

BETA
confocal microscopy
PCR

Software Mentioned

SI3r
NIH Image
Image
Object

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