Integrin alphavbeta6 is involved in measles protein-induced airway immune suppression

Cytokine
Xing-Mao WuBin Zang

Abstract

Measles infection causes immune suppression that contributes to morbidity and mortality of the patients; the mechanism is poorly understood. Regulatory T cells (Treg) play a critical role in immune suppression. Integrin alphavbeta6 (avb6) is associated with Treg's function. This study aims to investigate into the mechanism by which measles C protein (MVP)-induced avb6 contributes the generation of Tregs in the lung. MVP was introduced to mouse lung by nasal drops. The expression of avb6 by lung tissue was examined by reverse transcription polymerase chain reaction and Western blotting. The development of tolerogenic dendritic cells (DC) and Tregs in the lung and their functions was examined by flow cytometry. The suppressor function of MVP-induced Tregs was examined by cell culture models. The exposure to MVP markedly increased the expression of avb6 in the lung epithelial cells. Administration of MVP significantly suppressed the levels of IL-4 and IFNγ as well as increases in Tregs in lung tissue. DCs captured the MVP in the lung and differentiate into tolerogenic DCs; the latter has the ability to induce Treg development in the lung. Activation of MVP-induced Tregs powerfully suppressed polarized CD4(+) T cells. Exposure to M...Continue Reading

References

Sep 18, 1999·Respirology : Official Journal of the Asian Pacific Society of Respirology·A Y GohM Roziah
Aug 15, 2006·Immunological Reviews·Shimon SakaguchiTakashi Nomura
Mar 10, 2009·Cytokine & Growth Factor Reviews·Alfons Billiau, Patrick Matthys
Oct 27, 2009·Current Opinion in Immunology·Maria Bettini, Dario A A Vignali
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ho-Keun KwonSin-Hyeog Im
Jun 19, 2010·Nature Reviews. Immunology·Shimon SakaguchiDavid A Hafler
Jul 20, 2010·Immunological Reviews·Diane E Griffin
Dec 25, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·Constantin Ionescu-Tirgoviste, Florin Despa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.