PMID: 20646456Jul 22, 2010Paper

Integrin-associated proteins in blood plasma of patients with acute exacerbation of chronic obstructive pulmonary disease

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
Lei PanDe-qiong Dong

Abstract

To explore the role of CD(47) and P-selectin in patients with COPD. The blood plasma levels of CD(47) and P-selectin in 20 healthy volunteers (control group) and 35 patients with COPD in acute exacerbation and at stable stage were measured by flow cytometry. Platelet count was measured by hematology analyzer. SNK-q test and Pearson correlation analysis of the regression equation were used for statistics. The level of CD(47) in the COPD acute exacerbation group [(93 +/- 4)%] was significantly higher than that of the COPD stable group [(72 +/- 11)%] and that of the control group [(67 +/- 10)%], q = 11.26, 13.32, all P < 0.01, but the difference in CD(47) between the stable group and the control group was not significant (q = 1.73, P > 0.05). The level of P-selectin in the acute exacerbation group [(35 +/- 11)%] was significantly higher than those of the stable group [(12 +/- 8)%] and the control group [(10 +/- 4)%] (q = 9.93, 12.19, all P < 0.05), and the level of stable group was also higher than that of the control group (q = 1.90, P < 0.05). The difference in platelet counts among the acute exacerbation group [(188 +/- 56) x 10(9)/L], the stable group [(213 +/- 57) x 10(9)/L] and the control group [(204 +/- 51) x 10(9)/L] was ...Continue Reading

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