PMID: 7542659Aug 1, 1995Paper

Integrin beta 3 cytoplasmic tail is necessary and sufficient for regulation of alpha 5 beta 1 phagocytosis by alpha v beta 3 and integrin-associated protein

The Journal of Cell Biology
S D BlystoneE J Brown

Abstract

Using a K562 cell transfection model, we have previously described a novel relationship between the integrins alpha v beta 3 and alpha 5 beta 1. alpha v beta 3 ligation was able to inhibit alpha 5 beta 1-mediated phagocytosis without effect on alpha 5 beta 1-mediated adhesion. The alpha v beta 3-dependent inhibition apparently required a signal transduction cascade as it was reversed by inhibitors of serine/threonine kinases. Now, we have studied the mechanisms of signal transduction in this system and have found that the beta 3 cytoplasmic tail is both necessary and sufficient for initiation of the signal leading to inhibition of alpha 5 beta 1 phagocytosis. Ligation of integrin-associated protein (IAP), which has been implicated in alpha v beta 3 signal transduction, mimics the effects of alpha v beta 3 ligation only when the beta 3 integrin with an intact cytoplasmic tail is present. Although fibronectin-mediated phagocytosis requires the high affinity conformation of alpha 5 beta 1, ligation of alpha v beta 3/IAP does not prevent acquisition of this high affinity state. We conclude that alpha v beta 3/IAP ligation initates a signal transduction cascade, dependent upon the beta 3 cytoplasmic tail, which inhibits the phagocyt...Continue Reading

References

May 1, 1990·The Journal of Cell Biology·T DarribèreJ C Boucaut
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D A Cheresh
Aug 1, 1988·Cell Structure and Function·T YatohgoM Hayashi
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S D WrightS C Silverstein
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M LenterD Vestweber
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·D CooperM A Vadas
Oct 1, 1993·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·S D Blystone, J E Kaplan
Mar 1, 1993·The Journal of Cell Biology·I L GrahamE J Brown

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Citations

Feb 22, 2012·Cell and Tissue Research·Kyathanahalli S JanardhanBaljit Singh
Aug 9, 2005·Clinical & Experimental Metastasis·Christoph HeyderThomas Dittmar
Feb 5, 2003·Experimental Cell Research·Valeryi K LishkoTatiana P Ugarova
Feb 25, 2000·Thrombosis Research·K O YeeS M Schwartz
Jan 18, 2003·Molecular Immunology·Yuko J MiyamotoBradley W McIntyre
Nov 10, 2000·Advanced Drug Delivery Reviews·R J Parkes, S L Hart
Dec 24, 1997·Matrix Biology : Journal of the International Society for Matrix Biology·J W Smith
Feb 1, 1996·Current Opinion in Immunology·L A Allen, A Aderem
Dec 5, 2002·Cellular Microbiology·Yoshio IshibashiDavid A Relman
Oct 1, 1996·The Journal of Cell Biology·A G GaoW A Frazier
Sep 16, 2006·Human Gene Therapy·Kirsten A Weigel-KelleyArun Srivastava
Dec 1, 1996·Molecular Biology of the Cell·F Díaz-GonzálezM H Ginsberg
Feb 28, 2002·Annual Review of Immunology·David M Underhill, Adrian Ozinsky
Dec 2, 2011·Biological & Pharmaceutical Bulletin·Yutaro AzumaKojiro Matsumoto
Nov 25, 1997·Proceedings of the National Academy of Sciences of the United States of America·S C FinnemannE Rodriguez-Boulan
Sep 14, 2004·Leukemia & Lymphoma·Per-Arne Oldenborg
Feb 14, 1998·The Journal of Cell Biology·J M HigginsM B Brenner
Jun 1, 1996·Annals of Medicine·E J Brown, F P Lindberg
Dec 23, 2003·Journal of Cellular Biochemistry·Manolis C Demetriou, Anne E Cress
May 25, 2015·Biochimica Et Biophysica Acta·Raquel ReyesCarlos Cabañas
Jul 31, 2013·Biochimica Et Biophysica Acta·Mitali DasEdward F Plow
Aug 20, 2011·Immunobiology·Uday Kishore, Robert B Sim
Dec 27, 2011·Thrombosis Research·Mayumi YagiMichael Sobel
Jan 14, 2012·PloS One·Michael D L JohnsonMatthew R Redinbo

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