Integrin-dependent activation of the p70 ribosomal S6 kinase signaling pathway.

The Journal of Biological Chemistry
R K Malik, J T Parsons

Abstract

Interaction of the cell surface integrin receptors with extracellular matrix proteins results in the activation of intracellular signaling pathways, including activation of the p42/p44 mitogen-activated protein kinases. The protein tyrosine kinase focal adhesion kinase, or FAK, is linked to integrin signaling and interacts with several molecules involved in signal transduction. Here we report that exposure of fibroblast cells to extracellular matrix proteins activates the p70/p85 ribosomal S6 kinase (S6K) pathway in a ligand dependent manner. Treatment of cells with inhibitors of phosphatidylinositol 3-kinase, or FRAP (FKBP 12/rapamycin-associated protein) blocks integrin-mediated activation of S6K. In contrast to the integrin-directed activation of the mitogen-activated protein kinases, cytochalasin D treatment does not inhibit S6K activation. Treatment with the protein tyrosine kinase inhibitors herbimycin A and genistein completely blocks S6K activation, indicating a requirement for tyrosine kinase activity. Overexpression of the COOH-terminal noncatalytic domain of FAK, FRNK (FAK-related non-kinase) in chick embryo cells results in a significant reduction in the integrin-mediated activation of S6K and a concomitant reductio...Continue Reading

References

Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M D SchallerJ T Parsons
Oct 1, 1991·Current Opinion in Cell Biology·C E Turner, K Burridge
Mar 1, 1991·The Journal of Cell Biology·H M Blau, D Baltimore
Mar 1, 1994·Molecular and Cellular Biology·M D SchallerJ T Parsons
Oct 5, 1995·Nature·E J BrownS L Schreiber
Nov 1, 1995·The Journal of Cell Biology·S MiyamotoK M Yamada
Mar 1, 1995·Molecular Biology of the Cell·X Zhu, R K Assoian
Apr 14, 1995·Science·E A Clark, J S Brugge
Oct 1, 1994·Current Opinion in Cell Biology·D W DeSimone
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·H C Chen, J L Guan
Sep 1, 1994·The Journal of Cell Biology·V M LathamA F Ross
Feb 1, 1994·The Journal of Cell Biology·S M Frisch, H Francis
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·H B JefferiesG Thomas
May 20, 1994·Cell·E Ruoslahti, J C Reed
Sep 1, 1993·Molecular Biology of the Cell·J E MeredithM A Schwartz
Jan 1, 1993·Annual Review of Cell Biology·W G Stetler-StevensonL A Liotta
Feb 1, 1993·The Journal of Cell Biology·R L Juliano, S Haskill
May 13, 1993·Nature·H A LaneG Thomas

❮ Previous
Next ❯

Citations

Sep 27, 2001·Journal of Cellular Physiology·E H Danen, K M Yamada
Oct 24, 2007·Basic Research in Cardiology·William J TuxworthDhandapani Kuppuswamy
Oct 18, 2007·European Journal of Applied Physiology·Nelo Eidy Zanchi, Antonio Herbert Lancha
Mar 19, 2009·European Journal of Applied Physiology·Stephan KlossnerMartin Flueck
May 20, 2004·Experimental Cell Research·Leise A BervenMichael F Crouch
Oct 23, 1997·Current Opinion in Cell Biology·F G Giancotti
Dec 17, 1998·Trends in Cell Biology·M E Lukashev, Z Werb
Aug 1, 1997·The International Journal of Biochemistry & Cell Biology·J L Guan
Mar 13, 2003·Kidney International·Ravinder S ChanaDavid C Wheeler
Jul 5, 2008·Nucleosides, Nucleotides & Nucleic Acids·I V BijnsdorpG J Peters
Nov 25, 2003·Photochemistry and Photobiology·Mladen KorbelikPeter W Payne
Feb 24, 2001·American Journal of Clinical Pathology·D X CaiA Perry
May 13, 2009·Medicinal Research Reviews·Annelies BronckaersSandra Liekens
Jul 13, 2004·Biochimica Et Biophysica Acta·Stuart S Martin, Kristiina Vuori
Aug 12, 2003·The Journal of Biological Chemistry·Sundaravadivel Balasubramanian, Dhandapani Kuppuswamy
Sep 12, 1998·The Journal of Biological Chemistry·M LaserD Kuppuswamy
Aug 6, 2011·Journal of Applied Physiology·Kai ZouMarni D Boppart
Nov 14, 2001·The Journal of Biological Chemistry·O Jameel ShahLeonard S Jefferson
Aug 27, 2009·Expert Opinion on Therapeutic Targets·Francis Robert, Jerry Pelletier
Jun 1, 2004·Experimental Biology and Medicine·Joshua M LangEsther E Dupont-Versteegden
Apr 12, 2001·Journal of Applied Physiology·G A Nader, K A Esser
Jul 17, 1999·The American Journal of Physiology·M FlückF W Booth
Feb 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Kenji SakakibaraK Craig Kent
Jan 3, 2001·Journal of the American Society of Nephrology : JASN·John MartinRobert Steadman
Aug 14, 1999·Science·F G Giancotti, E Ruoslahti

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.