PMID: 9551745Apr 29, 1998Paper

Integrin dependent migration of lung cancer cells to extracellular matrix components

The European Respiratory Journal
C G BredinJ Klominek

Abstract

Since tumour progression is dependent on the ability of malignant cells to interact with the extracellular matrix (ECM), we have investigated the significance of beta1 and beta3 integrins for migration of lung cancer cells to components of the ECM. In an in vitro hapto- and chemotactic assay system, five cell lines representing the major types of lung cancer were examined: adenocarcinoma (WART); squamous cell carcinoma (U-1752); small cell lung cancer (SCLC) (U-1906, 054 A) and large cell lung cancer (LCLC) (U-1810). Flow cytometric analyses were performed to characterize their integrin expression. U-1906, 054 A, WART and U-1752 all expressed beta1 integrins whereas U-1810 did not. However, U-1810 and U-1752 expressed beta3 integrins. All cell lines except U-1810 and U-1752 showed hapto- and chemotactic motility to fibronectin, laminin and type IV collagen and this motility was beta1 integrin-dependent except in the case of U-1810. However, the hapto- and chemotactic responses differed markedly between the separate cell lines and there was no distinct pattern to separate non-small cell lung cancer (NSCLC) from SCLC. No or very little migration was seen in control experiments with bovine serum albumin (BSA) or serum-free medium ...Continue Reading

Citations

Mar 10, 2005·Virchows Archiv : an International Journal of Pathology·A SchützG Aust
Sep 11, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Jing QinBaoyu Chen
Aug 19, 2005·Journal of the American Society of Nephrology : JASN·Carolina HolménSuchitra Sumitran-Holgersson
Jan 5, 2007·Chemotherapy·Toshihiro WadaIsao Kubota
Jul 30, 2005·International Journal of Cancer. Journal International Du Cancer·Takashi OhtsukaYasunori Okada
Jul 10, 1999·International Journal of Cancer. Journal International Du Cancer·C G BredinJ Klominek

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