PMID: 7515549Mar 1, 1994Paper

Integrin expression in middle ear cholesteatoma

Acta Oto-laryngologica
S DallariG Girolomoni

Abstract

Cholesteatoma is lined by a squamous keratinizing epithelium exhibiting most of the features of normal epidermis. In this study, we investigated by immunohistochemistry the expression of integrin adhesion molecules in primary acquired and recurrent cholesteatomas, and compared it with common epidermal cysts and normal human skin. The results showed that cholesteatoma epithelium exhibited a markedly augmented expression of alpha v integrin subunit and a corresponding increased deposition of vitronectin (alpha v ligand) in the surrounding stroma as compared to epidermal cyst and normal human skin. In contrast, the expression pattern of alpha 2 beta 1, alpha 3 beta 1, and alpha 6 beta 4 integrins as well as the distribution of laminin, collagen IV and fibronectin were similar in cholesteatomas, epidermal cysts and normal human skin. Similar staining pattern was observed in primary acquired and recurrent cholesteatoma.

References

Jun 1, 1992·The Journal of Clinical Investigation·M D HertleF M Watt
Mar 1, 1990·The Journal of Cell Biology·H LarjavaK M Yamada
May 1, 1990·Archives of Otolaryngology--head & Neck Surgery·P P VennixF C Ramaekers
Apr 1, 1990·Experimental Cell Research·M J StaquetJ Thivolet
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M De LucaV Quaranta
Aug 1, 1990·The British Journal of Dermatology·C E KleinL Weber
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M J Elices, M E Hemler
Jan 1, 1989·Archives of Dermatological Research·U KonterW Sterry
Jul 1, 1983·Acta Oto-laryngologica·J SadéG Pinkus
May 1, 1993·Acta Oto-laryngologica·J BujíaE Kastenbauer
Oct 1, 1993·The Journal of Investigative Dermatology·A CavaniA Giannetti

❮ Previous
Next ❯

Citations

Jun 2, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Hans-J WelkoborskyMike L Hinni
May 1, 1996·Acta Oto-laryngologica·M SchönermarkT Lenarz
Mar 23, 1999·The Annals of Otology, Rhinology, and Laryngology·M P SchönermarkT Lenarz
Jun 7, 2003·The Laryngoscope·Masaharu TokurikiHitoshi Saito
Sep 3, 1999·Clinical Otolaryngology and Allied Sciences·S ErgünX Zheng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.