Integrin-Linked Kinase Activation Prevents Ventricular Arrhythmias Induced by Ischemia/Reperfusion Via Inhibition of Connexin 43 Remodeling.

Journal of Cardiovascular Translational Research
Ping ZhouYuqiang Fang

Abstract

Ischemia reperfusion (I/R)-induced arrhythmia is a serious complication in patients with cardiac infarction. Remodeling of connexin (Cx) 43, manifested as phosphorylation, contributes significantly to arrhythmogenesis. Integrin-linked kinase (ILK) attenuated ventricular remodeling and improved cardiac function in rats after myocardial infarction. We hypothesized that ILK, through Cx43 phosphorylation, would be protective against I/R-induced ventricular arrhythmias. Our study showed that I/R-induced ventricular arrhythmias were attenuated by an ILK agonist LPTP and worsened by the ILK inhibitor Cpd22. I/R disrupted Cx43 distribution, but it was partially normalized in the presence of LPTP. Compared with I/R, the phosphorylation of Akt was increased significantly after pretreatment with LPTP. The increase in phosphorylated Akt was physiologically significant because, in the presence of the Akt inhibitor MK2206, the protective effects of LPTP were blocked. This indicated that ILK activation prevented I/R-induced-ventricular arrhythmia, an effect potentially related to inhibition of Cx43 remodeling via Akt activation.

References

Oct 26, 2005·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Andry RakotovaoFrançois Boucher
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Kyle R LegateReinhard Fässler
Sep 2, 2006·Biochemical and Biophysical Research Communications·Yuankun YueMohamed Boutjdir
Oct 13, 2006·British Journal of Pharmacology·H Clements-Jewery
May 26, 2007·Circulation Research·Gregory E HanniganShoukat Dedhar
Dec 29, 2007·Cell Communication & Adhesion·Darren J ParkBonnie J Warn-Cramer
Jun 23, 2009·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Issei Imanaga
Dec 8, 2009·Journal of Molecular and Cellular Cardiology·David A BrownBrian O'Rourke
May 25, 2010·Biochemical and Biophysical Research Communications·Stephanie I BettinkErik B Friedrich
Apr 30, 2011·Circulation Research·Benjamin F RemoGlenn I Fishman
Oct 18, 2011·Pharmacological Reports : PR·Zuzana Broskova, Vladimir Knezl
Dec 6, 2011·The Journal of Biological Chemistry·Clarence A DunnPaul D Lampe
Jun 6, 2012·PloS One·Alexandra TraisterJohn G Coles
Jul 6, 2012·Current Opinion in Cell Biology·Jun Qin, Chuanyue Wu
Apr 19, 2013·Journal of Cardiovascular Pharmacology·Emiliano R DiezRoberto M Miatello
Jun 14, 2015·Circulation. Arrhythmia and Electrophysiology·Khai Le QuangStanley Nattel

❮ Previous
Next ❯

Citations

May 25, 2021·Therapeutic Hypothermia and Temperature Management·Zhenying NiuYanqiu Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.