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Integrin-mediated protein kinase A activation at the leading edge of migrating cells

Molecular Biology of the Cell

Sep 12, 2008

Chinten J LimMark H Ginsberg

Abstract

cAMP-dependent protein kinase A (PKA) is important in processes requiring localized cell protrusion, such as cell migration and axonal path finding. Here, we used a membrane-targeted PKA biosensor to reveal activation of PKA at the leading edge of migrating cells. Previous studies show ...read more

Mentioned in this Paper

Protrusion
Establishment and Maintenance of Localization
Cricetulus
Phosphatidylinositols
Reticulopodia
Phosphatidylinositol 3-Kinases
Cell Polarity
Cell Motility
Biosensors
Isoactin
Paper Details
References
  • References49
  • Citations50
12345
  • References49
  • Citations50
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Integrin-mediated protein kinase A activation at the leading edge of migrating cells

Molecular Biology of the Cell

Sep 12, 2008

Chinten J LimMark H Ginsberg

PMID: 18784251

DOI: 10.1091/mbc.e08-06-0564

Abstract

cAMP-dependent protein kinase A (PKA) is important in processes requiring localized cell protrusion, such as cell migration and axonal path finding. Here, we used a membrane-targeted PKA biosensor to reveal activation of PKA at the leading edge of migrating cells. Previous studies show ...read more

Mentioned in this Paper

Protrusion
Establishment and Maintenance of Localization
Cricetulus
Phosphatidylinositols
Reticulopodia
Phosphatidylinositol 3-Kinases
Cell Polarity
Cell Motility
Biosensors
Isoactin

Feeds With Similar Papers

Cytoskeleton & Cell Polarity

A dynamic cytoskeleton is critical for the generation of cell polarity. This feed focuses on cell polarity and the cytoskeleton, including actin and microtubular cytoskeletal organization.

Cytoskeleton & Cell Polarity

A dynamic cytoskeleton is critical for the generation of cell polarity. This feed focuses on cell polarity and the cytoskeleton, including actin and microtubular cytoskeletal organization.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Spatial regulation of the cAMP-dependent protein kinase during chemotactic cell migration

Proceedings of the National Academy of Sciences of the United States of AmericaSeptember 24, 2005
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Biochimica Et Biophysica Acta

Regulation of actin-based cell migration by cAMP/PKA

Biochimica Et Biophysica ActaJuly 13, 2004
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Paper Details
References
  • References49
  • Citations50
12345
  • References49
  • Citations50
12345

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