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Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment

Cancers

Aug 24, 2019

Nicholas F Brown, John F Marshall

Abstract

TGFβ (transforming growth factor-beta) is a pleotropic cytokine with contrasting effects in cancer. In normal tissue and early tumours, TGFβ acts as a tumour suppressor, limiting proliferation and inducing apoptosis. However, these effects are eventually abrogated by the loss or inactiv...read more

Mentioned in this Paper

Biochemical Pathway
Transforming Growth Factor beta
T-Lymphocyte
TGFA protein, human
Angiogenic Process
Regulation of Biological Process
Extracellular Matrix
Protein Localization Location
Neoplasms
Cell Proliferation
4
16
Paper Details
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Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment

Cancers

Aug 24, 2019

Nicholas F Brown, John F Marshall

PMID: 31438626

DOI: 10.3390/cancers11091221

Abstract

TGFβ (transforming growth factor-beta) is a pleotropic cytokine with contrasting effects in cancer. In normal tissue and early tumours, TGFβ acts as a tumour suppressor, limiting proliferation and inducing apoptosis. However, these effects are eventually abrogated by the loss or inactiv...read more

Mentioned in this Paper

Biochemical Pathway
Transforming Growth Factor beta
T-Lymphocyte
TGFA protein, human
Angiogenic Process
Regulation of Biological Process
Extracellular Matrix
Protein Localization Location
Neoplasms
Cell Proliferation
4
16

Similar Papers Found In These Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Integrins in Cancer Progression & Metastasis

The integrin family of cell adhesion receptors regulate diverse functions in cells and are implicated in the development, progression, and metastasis of solid tumors. Here is the latest research.

Related Papers

Cell and Tissue Research

The role of integrins in TGFβ activation in the tumour stroma

Cell and Tissue ResearchAugust 16, 2016
Zareen Khan, John F Marshall
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