Integrin signaling and mechanotransduction in regulation of somatic stem cells.

Experimental Cell Research
Aleksi IsomursuEmilia Peuhu

Abstract

Somatic stem cells are characterized by their capacity for self-renewal and differentiation, making them integral for normal tissue homeostasis. Different stem cell functions are strongly affected by the specialized microenvironment surrounding the cells. Consisting of soluble signaling factors, extracellular matrix (ECM) ligands and other cells, but also biomechanical cues such as the viscoelasticity and topography of the ECM, these factors are collectively known as the niche. Cell-ECM interactions are mediated largely by integrins, a class of heterodimeric cell adhesion molecules. Integrins bind their ligands in the extracellular space and associate with the cytoskeleton inside the cell, forming a direct mechanical link between the cells and their surroundings. Indeed, recent findings have highlighted the importance of integrins in translating biophysical cues into changes in cell signaling and function, a multistep process known as mechanotransduction. The mechanical properties of the stem cell niche are important, yet the underlying molecular details of integrin-mediated mechanotransduction in stem cells, especially the roles of the different integrin heterodimers, remain elusive. Here, we introduce the reader to the concep...Continue Reading

Citations

Jan 27, 2020·Development, Growth & Differentiation·Shah Adil Ishtiyaq AhmadKunimasa Ohta
Mar 28, 2020·Cell and Tissue Research·Abolfazl BarzegariGraciela Pavon-Djavid
Jul 18, 2020·Stem Cell Research & Therapy·Asmat Ullah KhanJingxing Dai
Sep 16, 2020·International Journal of Molecular Sciences·Jiro Takito, Masanori Nakamura
Oct 24, 2020·Current Stem Cell Reports·Paulina D HortonPamela L Wenzel
Feb 20, 2021·The FEBS Journal·Nikos K KaramanosMaurizio Onisto
Nov 15, 2020·Seminars in Cell & Developmental Biology·Oona Paavolainen, Emilia Peuhu
May 19, 2021·Cellular Signalling·Yasaswi Gayatri Mishra, Bramanandam Manavathi
Aug 8, 2021·International Journal of Molecular Sciences·Mattia PasquaMaria Giovanna Francipane

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