Integrins in development and cancer

Biophysics Reviews
Luke R AndersonMatthew J Naylor

Abstract

The correct control of cell fate decisions is critical for metazoan development and tissue homeostasis. It is established that the integrin family of cell surface receptors regulate cell fate by mediating cell-cell and cell-extracellular matrix (ECM) interactions. However, our understanding of how the different family members control discrete aspects of cell biology, and how this varies between tissues and is temporally regulated, is still in its infancy. An emerging area of investigation aims to understand how integrins translate changes in tension in the surrounding microenvironment into biological responses. This is particularly pertinent due to changes in the mechanical properties of the ECM having been linked to diseases, such as cancer. In this review, we provide an overview of the roles integrins play in important developmental processes, such as proliferation, polarity, apoptosis, differentiation and maintenance of "stemness". We also discuss recent advances in integrin mechanobiology and highlight the involvement of integrins and aberrant ECM in cancer.

References

Aug 1, 1995·Genes & Development·R Fässler, M Meyer
Feb 1, 1994·The Journal of Cell Biology·S M Frisch, H Francis
Sep 1, 1993·Molecular Biology of the Cell·J E MeredithM A Schwartz
Jul 1, 1996·Nature Genetics·E Georges-LabouesseM Le Meur
Jun 1, 1996·The Journal of Cell Biology·M Chrzanowska-Wodnicka, K Burridge
Jul 1, 1996·The Journal of Cell Biology·F MainieroF G Giancotti
Jul 1, 1996·The Journal of Cell Biology·J DowlingE Fuchs
May 5, 1997·The Journal of Cell Biology·C M DiPersioR O Hynes
Oct 6, 1997·The Journal of Cell Biology·W BlochR Fässler
May 18, 1999·International Journal of Cancer. Journal International Du Cancer·G FritzB Kaina
Sep 6, 2000·Trends in Genetics : TIG·A De Arcangelis, E Georges-Labouesse
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·H TaniP Kaur
Feb 13, 2001·Current Opinion in Genetics & Development·R K Assoian, M A Schwartz
Apr 27, 2001·Seminars in Cancer Biology·A M Mercurio, I Rabinovitz
Aug 4, 2001·Circulation Research·D BouvardR Fässler
Sep 7, 2001·Current Opinion in Cell Biology·A M MercurioL M Shaw
May 1, 2002·The Journal of Cell Biology·Emilio HirschFiorella Altruda
Aug 2, 2002·Cell·Benjamin Geiger, Alexander Bershadsky
Nov 26, 2002·The Journal of Cell Biology·Catherine G GalbraithMichael P Sheetz
Feb 27, 2004·Journal of Mammary Gland Biology and Neoplasia·Ilaria TaddeiMarina A Glukhova
Dec 3, 2004·Molecular Biology of the Cell·Wei YuMirjam M P Zegers

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Citations

Oct 15, 2018·Journal of Cellular Physiology·Xin-Yue LianJun Qian
Jul 11, 2020·Advanced Biosystems·Solveig M BarteltSeraphine V Wegner
Nov 6, 2020·OncoTargets and Therapy·Xiang-Qiong WenJia-Ping Hu

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