Integrins mediate mechanical compression-induced endothelium-dependent vasodilation through endothelial nitric oxide pathway

The Journal of General Physiology
Xiao Lu, Ghassan S Kassab

Abstract

Cardiac and skeletal muscle contraction lead to compression of intramuscular arterioles, which, in turn, leads to their vasodilation (a process that may enhance blood flow during muscle activity). Although endothelium-derived nitric oxide (NO) has been implicated in compression-induced vasodilation, the mechanism whereby arterial compression elicits NO production is unclear. We cannulated isolated swine (n = 39) myocardial (n = 69) and skeletal muscle (n = 60) arteriole segments and exposed them to cyclic transmural pressure generated by either intraluminal or extraluminal pressure pulses to simulate compression in contracting muscle. We found that the vasodilation elicited by internal or external pressure pulses was equivalent; moreover, vasodilation in response to pressure depended on changes in arteriole diameter. Agonist-induced endothelium-dependent and -independent vasodilation was used to verify endothelial and vascular smooth muscle cell viability. Vasodilation in response to cyclic changes in transmural pressure was smaller than that elicited by pharmacological activation of the NO signaling pathway. It was attenuated by inhibition of NO synthase and by mechanical removal of the endothelium. Stemming from previous obse...Continue Reading

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Citations

Oct 13, 2017·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Juan Martín-HernándezAlejandro Lucia
Nov 9, 2017·Journal of Exercise Rehabilitation·Kwang-Seok Hong, Kijeong Kim
Jan 1, 2020·American Journal of Physiology. Cell Physiology·Yaqiu LiLinda J Lowe-Krentz
Aug 17, 2020·European Journal of Pharmacology·Alejandra Garate-CarrilloIsrael Ramirez-Sanchez
Jan 13, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hai-Ying ChenLe-Xin Wang

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