Integrity of hypothalamic fibers and cognitive fatigue in multiple sclerosis

Multiple Sclerosis and Related Disorders
Katrin HankenHelmut Hildebrandt

Abstract

Cognitive fatigue is a common and disabling symptom of multiple sclerosis (MS), but little is known about its pathophysiology. The present study investigated whether the posterior hypothalamus, which is considered as the waking center, is associated with MS-related cognitive fatigue. We analyzed the integrity of posterior hypothalamic fibers in 49 patients with relapsing-remitting MS and 14 healthy controls. Diffusion tensor imaging (DTI) parameters were calculated for fibers between the posterior hypothalamus and, respectively, the mesencephalon, pons and prefrontal cortex. In addition, DTI parameters were computed for fibers between the anterior hypothalamus and these regions and for the corpus callosum. Cognitive fatigue was assessed using the Fatigue Scale for Motor and Cognitive Functions. Analyses of variance with repeated measures were performed to investigate the impact of cognitive fatigue on diffusion parameters. Cognitively fatigued patients (75.5%) showed a significantly lower mean axial and radial diffusivity for fibers between the posterior hypothalamus and the mesencephalon than cognitively non-fatigued patients (Group(⁎)Target area(⁎)Diffusion orientation: F=4.047; p=0.023). For fibers of the corpus callosum, MS...Continue Reading

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Citations

Aug 19, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K HankenH Hildebrandt
Dec 10, 2015·Frontiers in Cellular Neuroscience·Moussa A ChalahSamar S Ayache
Jul 23, 2016·Der Nervenarzt·C Veauthier, F Paul
Mar 13, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Ruth MurphyBrian Hallahan
Jan 27, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Zina-Mary ManjalyKlaas Enno Stephan
Sep 20, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Miklos Palotai, Charles Rg Guttmann
Aug 22, 2017·American Journal of Physical Medicine & Rehabilitation·Sung Ho Jang, Hyeok Gyu Kwon
Aug 1, 2018·Frontiers in Neurology·Katrin HankenHelmut Hildebrandt
Mar 25, 2019·Journal of the Neurological Sciences·Jameen ArmSaadallah Ramadan

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