PMID: 8589344Jan 1, 1995Paper

Integrity of myosin light chain kinase is essential for Ito cell contraction

Journal of Gastroenterology and Hepatology
S WatanabeN Sato

Abstract

Hepatic sinusoidal Ito cells (fat storing cells) are believed to play a regulatory role on hepatic sinusoidal blood flow through their contraction. The detailed mechanism of contraction of Ito cells, however, is still unknown. The present study was undertaken to clarify the effect of new myosin light chain kinase inhibitor, wortmannin, on Ito cell contraction. Ito cells prepared from rat liver were cultured for 4 days before the study. The contraction of Ito cells, which was monitored and analysed by time-lapse video tape recording, was triggered by addition of endothelin-1. Wortmannin pretreatment for 1 h inhibited endothelin-induced Ito cell contraction dose-dependently. Therefore, the integrity of the actomyosin system is essential for Ito cell contraction and normal sinusoidal blood flow.

References

Jul 15, 1992·The Biochemical Journal·N KawadaK Decker
Jun 30, 1992·Biochemical and Biophysical Research Communications·M Ohara-ImaizumiK Kumakura
Jul 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B DescosD Alagille
Oct 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M SakamotoK Tanikawa
Mar 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M GotoH Fusamoto
Mar 15, 1994·Biochemical and Biophysical Research Communications·S WatanabeN Sato

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Citations

Sep 1, 1998·Journal of Gastroenterology and Hepatology·Xian-En WangNobuhiro Sato

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