Feb 25, 2005

Integrons and transposons on the Salmonella enterica serovar typhimurium virulence plasmid

Antimicrobial Agents and Chemotherapy
Laura Villa, Alessandra Carattoli

Abstract

A virulence plasmid was identified in a multidrug-resistant Salmonella enterica serotype Typhimurium strain carrying the spvC, rck, and pefA virulence genes and two class 1 integrons linked to the Tn21 and Tn1696 transposons. A novel trimethoprim resistance gene, designated dfrA23, was also identified within the integron region. The association of multidrug resistance and virulence determinants represents an interesting example of virulence plasmid evolution.

Mentioned in this Paper

Pathogenicity
Salmonella enterica
Trimethoprim
Integrons
Virulence
Plasmids
Drug Resistance, Multiple, Bacterial
Salmonella typhimurium LT2
resistance genes
DNA Transposons

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.