PMID: 9193943May 1, 1997Paper

Integument ultrastructure of Oestrus ovis (L.) (Diptera:Oestridae) larvae: host immune response to various cuticular components

International Journal for Parasitology
L InnocentiF Giorgi

Abstract

The nasal bot fly, Oestrus ovis, was investigated to establish which specific cuticular component is most immunogenic to infested sheep and how larval cuticle attains a protective role, if any, against the host immune system. To accomplish these goals, larval cuticle was extracted by a variety of agents and tested against immune sera from infested sheep and experimentally immunized rabbits. The cuticle substructure remaining after extraction was examined to localize various immunogenic components. O. ovis larval integument comprises an inner cellular layer, the epidermis, and an overlying cuticle layer. In 3rd instar larvae, the cuticle comprises 2 additional layers: the procuticle with numerous pore canals and the epicuticle which includes the wax canals. Three additional layers, altogether comprising the cuticulin layer, are present external to the epicuticle. The epicuticle is completed by apposition of an amorphous electrondense material extending for up to 1 micron in thickness. When fixed with ruthenium red, cuticle becomes heavily stained all along the epicuticular surface in larvae of all developmental stages. However, in 3rd instar larvae, ruthenium red deposits are restricted to the cuticulin layer alone. By gel elect...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Aug 1, 1987·International Journal for Parasitology·P J Skelly, A J Howells
Aug 1, 1973·Experimental Parasitology·S H WeisbrothS Scher
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Aug 7, 1946·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R DENNELL

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Citations

Dec 2, 2009·Experimental Parasitology·Piermarino MililloDomenico Otranto
Oct 1, 2010·Medical and Veterinary Entomology·C E Angulo-ValadezR Cepeda-Palacios
Sep 4, 2015·Journal of Medical Entomology·Kristina FriesenDavid B Taylor
Mar 24, 2000·Journal of Medical Entomology·R Cepeda-Palacios, P J Scholl
Sep 25, 2007·Journal of Morphology·Jan SobotníkJan Hubert

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