Apr 14, 2020

The Medial Temporal Lobe Supports Mnemonic Discrimination For Event Duration

BioRxiv : the Preprint Server for Biology
N. Muncy, Brock Kirwan


Time has an integral role in episodic memory and previous work has implicated the medial temporal lobe in both representing time and discriminating between similar information. Here we developed a novel paradigm to test mnemonic discrimination for temporal duration, as previous work has largely focused on order or maintaining information over time. Thirty-five healthy, young adults completed a continuous-recognition, temporal discrimination task in which participants were tasked with detecting a change in stimulus duration on the order of 0.5 seconds. Whole-brain high-resolution fMRI data were acquired. Behavioral results indicate that participants were successful at detecting whether or not the stimulus duration changed. Further, fMRI analyses revealed that the left entorhinal and perirhinal cortices were differentially involved in encoding and retrieval, respectively. These findings support the notion of the entorhinal cortex being involved in the encoding of temporal context information as well as the perirhinal cortex representing the conjunction of item and context during retrieval.

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