Intelligent use of NSAIDs--where do we stand?

Expert Opinion on Pharmacotherapy
R G Berger

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are drugs commonly prescribed for a variety of medical conditions. They are potent pharmacological agents efficacious for inflammatory conditions, but have significant gastrointestinal (GI), renal and haematological toxicity that must not be taken lightly. The newer, more cyclooxygenase-(COX)-2-selective NSAIDs, have no effects on platelet function and little GI toxicity, but do have renal physiological effects. The superiority of one NSAID over another has not been clinically demonstrated in musculoskeletal conditions, nor has the efficacy of NSAIDs in non-inflammatory rheumatic conditions been shown to be better than that of simple analgesics. NSAIDs are indicated for primary therapy of inflammatory rheumatic diseases and the more selective COX-2 agents should be employed as first choice when economically feasible. NSAIDs should not be used indiscriminately for non-inflammatory osteoarthritis or musculoskeletal injuries, particularly in the elderly patient, in whom alternative, less toxic therapy should be sought.

References

Jun 13, 1991·The New England Journal of Medicine·P M Brooks, R O Day
Sep 1, 1988·Annals of Internal Medicine·M R GriffinW Schaffner
Jan 1, 1987·The American Journal of Sports Medicine·P K NikolaouW E Garrett
Mar 1, 1984·The New England Journal of Medicine·D M Clive, J S Stoff
Jan 1, 1984·Annual Review of Medicine·M J Dunn
Jul 1, 1994·The American Journal of Sports Medicine·W T ObremskyW E Garrett
Dec 1, 1993·The American Review of Respiratory Disease·E IsraelJ M Drazen
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J A MitchellJ R Vane
Aug 9, 1993·The American Journal of Medicine·D L DeWittW L Smith
May 1, 1993·Gastroenterologia Japonica·S K Lam
Jan 16, 1998·The American Journal of Medicine·T R LevinJ V Selby
Apr 30, 1998·Annals of Medicine·P Isomäki, J Punnonen
Apr 9, 1999·The Journal of Clinical Investigation·H F ChengR C Harris
Jul 2, 1999·The American Journal of Medicine·J B Lefkowith
Dec 2, 1999·JAMA : the Journal of the American Medical Association·L S SimonG S Geis
Dec 28, 1999·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S BavbekZ Misirligil
Sep 9, 2000·Annals of Internal Medicine·G WolfR A Stahl

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Citations

Jul 30, 2008·Blood Pressure·Talma Rosenthal, Naomi Nussinovitch
Dec 9, 2004·The Journal of Arthroplasty·Mark L WangRocky S Tuan
May 5, 2001·Expert Opinion on Pharmacotherapy·A Bennett
Mar 5, 2004·Paediatric Anaesthesia·Brian J Anderson
Nov 20, 2002·Dental Clinics of North America·Marc W Heft, Angelo J Mariotti

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