Intense aerobic exercise lowers blood pressure in individuals with metabolic syndrome taking antihypertensive medicine

Blood Pressure Monitoring
M Ramirez-JimenezR Mora-Rodriguez

Abstract

There is a growing tendency for physicians to prescribe exercise in accordance with the 'exercise is medicine' global health initiative. However, the exercise-pharmacologic interactions for controlling blood pressure are not well described. Our purpose was to study whether angiotensin II receptor type 1 blocker (ARB) antihypertensive medicine enhances the blood pressure-lowering effects of intense exercise. Fifteen hypertensive individuals with metabolic syndrome chronically medicated with ARB underwent two exercise trials in a blind randomized order. One trial was conducted after taking their habitual dose of ARB (ARB MED trial) and another after 48 h of placebo medicine (i.e. dextrose; PLAC trial). After placebo medication, brachial systolic blood pressure increased by 5.5 mmHg [P=0.009; effect size (ES)=0.476] and diastolic by 2.5 mmHg (P=0.030; ES=0.373). Exercise reduced systolic and diastolic blood pressures to the same extent in ARB MED and PLAC trials (7 and 8 mmHg, respectively, for systolic and 5 and 4 mmHg, respectively, for diastolic, all P<0.05). Pulsatile measures of arterial stiffness did not reveal an interaction effect between exercise and medication. However, postocclusion reactive hyperemia increased after ex...Continue Reading

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Citations

Mar 5, 2021·Scandinavian Journal of Medicine & Science in Sports·Miguel Ramirez-JimenezRicardo Mora-Rodriguez

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Methods Mentioned

BETA
PLAC

Clinical Trials Mentioned

NCT03019796

Software Mentioned

SphygmoCor
SPSS

Related Concepts

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