Intense pruritus and failure to thrive in Alagille syndrome

Journal of the American Academy of Dermatology
Rodrigo SchwartzDean S Morrell

Abstract

A 4-year-old girl with failure to thrive and intense pruritus associated with Alagille syndrome is described. The clinical features of this autosomal dominant disorder are reviewed. This case highlights the importance of recognizing the severe pruritus as a manifestation of the disease.

References

Jun 1, 1973·Archives of Disease in Childhood·G H Watson, V Miller
Jul 9, 1998·Pediatric Dermatology·D A BuckleyA W du Vivier
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K M EmerickD A Piccoli
Aug 5, 2000·American Journal of Medical Genetics·N C HoV Ho
May 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karan M Emerick, Peter F Whitington
Sep 24, 2002·American Journal of Medical Genetics·Binita M KamathIan D Krantz
Jan 22, 2005·Pediatric Dermatology·Maria Amelia GarciaMaria Teresa de Davila

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Citations

May 4, 2017·Case Reports in Pediatrics·Alisa Brennan, Anil Kesavan

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Alagille syndrome is a multi-system genetic disorder that can affect the liver, heart, and other parts of the body. It’s characterization includes heart problems, liver damage, jaundice, and xanthomas. Here is the latest research.