Intense vasoconstriction in response to aspirate from stented saphenous vein aortocoronary bypass grafts

Journal of the American College of Cardiology
Kirsten LeineweberG Heusch

Abstract

We sought to identify soluble vasoconstrictor substances that are released during stent implantation into saphenous vein aortocoronary bypass grafts. Atherosclerotic saphenous vein aortocoronary bypass grafts are particularly vulnerable to plaque rupture. Protection devices prevent particulate debris from being embolized. Additional soluble vasoconstrictor substances possibly also contribute to impaired microvascular perfusion. Peripheral venous blood (VB) and aspirate (AS) were obtained from 14 patients with a significant stenosis in a saphenous vein graft during stent implantation under protection with a distal balloon occlusion device. In five additional patients, arterial blood (AB) was also taken distal to the stented lesion before intervention. Vasomotor substances in VB, AB, and AS plasma were identified in a bioassay of rat mesenteric arteries with intact (+E) and denuded endothelium (-E). Vasoconstriction was normalized to that induced by potassium chloride depolarization (100%). Venous blood, AB, and AS plasma induced maximum vasoconstriction within six minutes. The AS plasma induced a vasoconstriction of 138 +/- 13% (-E) and 87 +/- 14% (+E); VB, of 70 +/- 14% (-E) and 23 +/- 4% (+E); and AB plasma obtained before int...Continue Reading

References

Feb 24, 1994·The New England Journal of Medicine·P GolinoJ T Willerson
Apr 3, 1993·Lancet·J P OttervangerB H Stricker
Nov 6, 1993·BMJ : British Medical Journal·J P OttervangerB H Stricker
Jul 18, 2000·Journal of the American College of Cardiology·R Erbel, G Heusch
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P S PenglisM J James
Feb 24, 2001·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M DemasiL G Cleland
Mar 20, 2002·Circulation·Donald S BaimUNKNOWN Saphenous vein graft Angioplasty Free of Emboli Randomized (SAFER) Trial Investigators
Apr 13, 2002·The American Journal of Cardiology·Eberhard GrubeUNKNOWN Saphenous Vein Graft Angioplasty Free of Emboli (SAFE) Trial Study Group
Nov 1, 2003·Thrombosis Research·Paola Patrignani
Sep 20, 2005·Journal of the American College of Cardiology·Peter J MasonJane E Freedman

❮ Previous
Next ❯

Citations

Aug 18, 2006·Basic Research in Cardiology·Andreas SkyschallyGerd Heusch
Feb 5, 2009·Basic Research in Cardiology·Yanping Liu, David D Gutterman
Jun 15, 2012·Wiener medizinische Wochenschrift·Petra KleinbongardGerd Heusch
Oct 18, 2011·Cardiovascular Research·Gerd HeuschRaimund Erbel
Jan 12, 2013·Cardiovascular Diabetology·Theodor BaarsPetra Kleinbongard
Jul 19, 2011·Journal of Molecular and Cellular Cardiology·Petra KleinbongardGerd Heusch
Jun 30, 2011·Journal of Molecular and Cellular Cardiology·Bryan G Schwartz, Robert A Kloner
Jan 31, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Mabelle YoungPaul Erne
Dec 7, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Nikhil KapoorMassoud A Leesar
Aug 9, 2008·Journal of the American College of Cardiology·Carl J Pepine
Oct 14, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Theodor BaarsPetra Kleinbongard
Jul 4, 2007·Expert Review of Cardiovascular Therapy·William J van Gaal, Adrian P Banning
Nov 4, 2009·Circulation·Gerd HeuschRaimund Erbel
May 14, 2016·Circulation Research·Gerd Heusch
Jan 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Dirk BöseGerd Heusch
Aug 13, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Petra KleinbongardGerd Heusch
Jun 12, 2013·Nature Reviews. Cardiology·Tim P van de HoefJan J Piek
Apr 30, 2014·Nature Reviews. Cardiology·Fergus M O'Farrell, David Attwell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.