Intensification of long-term memory deficit by chronic stress and prevention by nicotine in a rat model of Alzheimer's disease

Molecular and Cellular Neurosciences
K A AlkadhiTrinh T Tran

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cholinergic dysfunction and deposition of beta-amyloid (Aβ) in regions of the brain associated with learning and memory. The sporadic nature and late onset of most AD cases suggests that aside from biological determinants, environmental factors such as stress may also play a role in the progression of the disease. Behavioral and molecular studies were utilized to evaluate the effects of chronic nicotine treatment in the prevention of impairment of long-term memory. The rat model of AD was induced by i.c.v. osmotic pump infusion of Aβ peptides. Chronic psychosocial stress and chronic nicotine treatment were instituted for 6weeks. Spatial memory testing in the Radial Arm Water Maze revealed that, although stress, by itself, did not affect long-term memory, the combination of chronic stress and Aβ infusion impaired long-term memory significantly more than Aβ peptides infusion alone. Chronic nicotine treatment completely prevented Aβ- and stress/Aβ combination-induced memory impairment. Furthermore, molecular findings in hippocampal CA1 region of stress/Aβ rats indicated marked reduction in the protein levels of phosphorylated cAMP response elemen...Continue Reading

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Citations

Oct 17, 2012·The International Journal of Neuropsychopharmacology·Karem H AlzoubiKarim A Alkadhi
Mar 2, 2011·The International Journal of Neuropsychopharmacology·Karim A AlkadhiTrinh T Tran
Jun 20, 2018·The Journal of Pharmacology and Experimental Therapeutics·Karim A Alkadhi
Sep 26, 2015·Pharmacological Reviews·Esa R KorpiGavin S Dawe
Apr 18, 2017·Human & Experimental Toxicology·S MahdaviN H Roodbari
May 1, 2021·International Journal of Molecular Sciences·Kinga SałaciakKarolina Pytka

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