Intensification regimen for advanced-stage resectable hypopharyngeal carcinoma

Archives of Otolaryngology--head & Neck Surgery
Enver OzerDavid E Schuller

Abstract

To determine feasibility, compliance, long-term survival, and disease control rates in the intensification regimen for advanced resectable hypopharyngeal carcinoma. Prospective, nonrandomized, controlled phase 2 trial with a median follow-up period of 89 months (range, 3.4-140.0 months). Cancer center at a state university. Thirty-two patients (age range, 44-79 years; median age, 59 years) with advanced (69% stage IV, 31% stage III) resectable hypopharyngeal carcinoma. Combination of surgery, radiation therapy, and chemotherapy (cisplatin and paclitaxel) along with intraoperative radiation therapy. Compliance, long-term survival, and locoregional and systemic disease control rates and functional outcome. The protocol compliance rate was 62% (20 of 32 patients), and the overall 5-year survival rate was 56%. Local recurrence occurred in 3 patients (9%). The systemic disease control rate was 91% (29 of 32 patients). Total laryngectomy was required in 15 patients (47%); preservation of the larynx was possible in 17 patients (53%). Only 3 (13%) of 6 patients were percutaneous endoscopic gastrostomy tube dependent in the long-term follow-up. The intensification regimen described in this study accomplished excellent long-term survival...Continue Reading

Citations

Mar 7, 2007·Expert Review of Anticancer Therapy·Par S Mehta, Louis B Harrison
Mar 5, 2020·Laryngoscope Investigative Otolaryngology·Ciaran LaneNorbert Viallet

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