Abstract
Bone metastases occur in more than one-third of patients with advanced lung cancer and are difficult to treat. We showed previously the therapeutic effect of a third-generation bisphosphonate, minodronate, and anti-parathyroid hormone-related protein (PTHrP) neutralizing antibody on bone metastases induced by the human small cell lung cancer cell line, SBC-5, in natural killer cell-depleted severe combined immunodeficient mice. The purpose of our current study was to examine the effect of the combination of PTHrP antibody and zoledronic acid, which has been approved to treat bone metastases, against bone metastases produced by SBC-5 cells expressing PTHrP. Treatment with PTHrP antibody and/or zoledronic acid did not affect the proliferation of SBC-5 cells in vitro. Repeated treatments with either PTHrP antibody or zoledronic acid inhibited the formation of osteolytic bone metastases of SBC-5 cells but had no effect on metastases to visceral organs. Importantly, combined treatment with PTHrP antibody and zoledronic acid further inhibited the formation of bone metastases. Histologic assays showed that, compared with either PTHrP antibody or zoledronic acid alone, their combination decreased the number of tumor-associated osteocla...Continue Reading
References
Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Dec 1, 1991·Calcified Tissue International·A M Flanagan, T J Chambers
May 25, 1984·Journal of Immunological Methods·L M GreenC F Ware
Jun 26, 1993·Lancet·H GurneyT J Martin
Sep 1, 1993·The Journal of Experimental Medicine·T TanakaM Miyasaka
Jul 17, 1996·International Journal of Cancer. Journal International Du Cancer·S YanoS Sone
Oct 1, 1996·The Journal of Clinical Investigation·T A GuiseG R Mundy
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·S A RabbaniD Goltzman
Mar 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B E HillnerD G Pfister
Jul 18, 2000·Cancer·T A Guise
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P MajorJ Seaman
May 18, 2001·Nature·L A Liotta, E C Kohn
Jun 13, 2001·Seminars in Oncology·R L Theriault, G N Hortobagyi
Aug 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G D Roodman
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·H IguchiE Ogata
Dec 21, 2002·Differentiation; Research in Biological Diversity·Isaiah J Fidler
Jun 26, 2003·Cancer Science·Seiji YanoSaburo Sone
Aug 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lee S RosenJohn J Seaman
Dec 30, 2003·International Journal of Cancer. Journal International Du Cancer·Toyokazu MikiSaburo Sone
Apr 16, 2004·The New England Journal of Medicine·G David Roodman
Jun 16, 2004·Cancer·Lee S RosenJohn Seaman
Jul 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Toru HiragaToshiyuki Yoneda
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Etsuro OnumaEtsuro Ogata
Dec 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroaki MugurumaSaburo Sone
Sep 6, 2007·Cancer Metastasis Reviews·Saburo Sone, Seiji Yano
Feb 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hye-Suk HanNoe Kyeong Kim
Citations
Jul 26, 2011·Clinical & Experimental Metastasis·Ning-Qiang MaHe-Long Zhang
Dec 30, 2010·Cancer Research·Rachelle W JohnsonJulie A Sterling
Oct 1, 2010·Therapeutic Advances in Endocrinology and Metabolism·Richard Carroll, Glenn Matfin
Jun 1, 2011·PloS One·Isabella W Y MakMichelle Ghert
Sep 18, 2015·International Journal of Cancer. Journal International Du Cancer·Shinji TakeuchiSeiji Yano
Jul 27, 2010·Bone·Philippe Clézardin
Oct 1, 2011·Cancer Science·Ming ZhaoMasao Tanaka
Sep 15, 2005·Molecular Cancer·Giancarlo Ghiselli, Chang-Gong Liu
Nov 5, 2015·PloS One·San Jiun ChaiKue Peng Lim
Nov 21, 2014·PloS One·Taisuke MatsuoToyomasa Katagiri
Aug 13, 2005·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Angels Sierra
Jan 1, 2012·Cancers·Andrea KiesslingMarc Schmitz
Jan 1, 2011·Cancers·Claudio Luparello