Intensity- and interval-specific repetitive traumatic brain injury can evoke both axonal and microvascular damage.

Journal of Neurotrauma
Motoki FujitaJohn T Povlishock

Abstract

In the experimental setting several investigators have recently reported exacerbations of the burden of axonal damage and other neuropathological changes following repetitive traumatic brain injuries (TBI) that were sustained at intervals from hours to days following the initial insult. These same studies also revealed that prolonging the interval between the first and second insult led to a reduction in the burden of neuropathological changes and/or their complete elimination. Although demonstrating the capability of repetitive TBI to evoke increased axonal and other neuropathological changes, these studies did not address the potential for concomitant microvascular dysfunction or damage, although vascular dysfunction has been implicated in the second-impact syndrome. In this study we revisit the issue of repetitive injury in a well-controlled animal model in which the TBI intensity was bracketed from subthreshold to threshold insults, while the duration of the intervals between the injuries varied. Employing cranial windows to assess vascular reactivity and post-mortem amyloid precursor protein (APP) analysis to determine the burden of axonal change, we recognized that subthreshold injuries, even when administered in repeated...Continue Reading

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Citations

Aug 27, 2013·Neuropsychology Review·Erin D Bigler
Dec 25, 2012·Journal of Neurotrauma·John T Povlishock
Sep 19, 2014·Journal of Neuropathology and Experimental Neurology·Amanda N Bolton, Kathryn E Saatman
Oct 24, 2018·Journal of Neurotrauma·Amanda N Bolton-HallKathryn E Saatman
Nov 6, 2015·Frontiers in Neurology·Ryan C TurnerAnthony L Petraglia
Dec 20, 2015·Journal of Neurophysiology·Vladislav Volman, Laurel J Ng
Nov 19, 2015·Frontiers in Neurology·Ryan C TurnerCharles L Rosen
Sep 22, 2017·Cell Transplantation·Brooke Fehily, Melinda Fitzgerald
Apr 28, 2016·Journal of Neuroscience Research·Amandine JullienneJerome Badaut
Jun 26, 2018·Journal of Neuropathology and Experimental Neurology·Yasuaki OginoJohn T Povlishock
Mar 15, 2020·Neuro-Chirurgie·J EngelhardtH Loiseau
Feb 9, 2020·Journal of the Neurological Sciences·Samer El HayekFiras Kobeissy

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