Intensity modulated Ir-192 brachytherapy using high-Z 3D printed applicators

Physics in Medicine and Biology
Lawrie B SkinnerElizabeth A Kidd

Abstract

Gynecologic cancers are often asymmetric, yet current Ir-192 brachytherapy techniques provide only limited radial modulation of the dose. The shielded solutions investigated here solve this by providing the ability to modulate between highly asymmetric and radially symmetric dose distributions at a given location. To find applicator designs that can modulate between full dose and less than 50% dose, at the dimensions of the urethra, a 2D calculation algorithm was developed to narrow down the search space. Two shielding design types were then further investigated using Monte Carlo and Boltzmann-solver dose calculation algorithms. 3D printing techniques using ISO 10993 certified biocompatible plastics and 3D printable tungsten-loaded plastics were tested. It was also found that shadowing effects set by the shape of the shielding cannot be easily modulated out, hence careful design is required. The shielded applicator designs investigated here, allow for reduction of the dose by over 50% at 5 mm from the applicator surface in desired regions, while also allowing radially symmetric dose with isodose line deviations less than 0.5 mm from circular. The shielding designs were also chosen with treatment delivery time in mind. Treatment...Continue Reading

References

Dec 29, 2000·Medical Physics·A AngelopoulosP Sandilos
Jan 24, 2012·Brachytherapy·Sushil BeriwalUNKNOWN American Brachytherapy Society
Jul 10, 2012·Magnetic Resonance Imaging·Andriy FedorovRon Kikinis
Jan 10, 2013·Medical Physics·Matthew J WebsterWilliam Y Song
May 18, 2013·Physics in Medicine and Biology·Wenjun YangRyan T Flynn
Sep 7, 2013·Medical Physics·Matthew J WebsterWilliam Y Song
Apr 23, 2014·International Journal of Radiation Oncology, Biology, Physics·Dae Yup HanWilliam Y Song
Aug 6, 2015·Clinical and Translational Science·Robert J MorrisonKevin J Weatherwax
Apr 27, 2019·International Journal of Radiation Oncology, Biology, Physics·Cameron M CallaghanYusung Kim

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Citations

Aug 13, 2021·Physics in Medicine and Biology·Hyojun ParkChul Hee Min
Oct 29, 2021·Physics in Medicine and Biology·William Y SongXun Jia
Dec 15, 2021·Physics in Medicine and Biology·José VedelagoOliver Jäkel

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