Intensity-modulated radiation therapy for definitive treatment of cervical cancer: a meta-analysis

Radiation Oncology
Yanzhu LinXinping Cao

Abstract

To compare the efficacies and toxicities of intensity-modulated radiotherapy (IMRT) with three-dimensional conformal radiotherapy (3D-CRT) or conventional two-dimensional radiotherapy (2D-RT) for definitive treatment of cervical cancer. A meta-analysis was performed using search engines, including PubMed, Cochrane Library, Web of Science, and Elsevier. In the meta-analysis, odds ratios (ORs) were compared for overall survival (OS), disease-free survival (DFS), and acute and chronic toxicities. Included data were analysed using RevMan 5.2 software. Six studies encompassing a total of 1008 patients who received definitive treatment (IMRT = 350, 3-DCRT/2D-RT = 658) were included in the analysis. A comparison of 3-year OS and 3-year DFS revealed no significant differences between IMRT and 3D-CRT or 2D-RT (3-year OS: OR = 2.41, 95% confidence interval [CI]: 0.62-9.39, p = 0.21; 3-year DFS: OR = 1.44, 95% CI: 0.69-3.01, p = 0.33). The incidence of acute gastrointestinal (GI) toxicity and genitourinary (GU) toxicity in patients who received IMRT was significantly lower than that in the control group (GI: Grade 2: OR = 0.5, 95% CI: 0.28-0.89, p = 0.02; Grade 3 or higher: OR = 0.55, 95% CI: 0.32-0.95, p = 0.03; GU: Grade 2: OR = 0.41, 9...Continue Reading

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Citations

May 23, 2019·Cancer Cell International·Yanzhu LinXinping Cao
Nov 26, 2019·American Journal of Clinical Oncology·Gustavo A VianiJuliana F Pavoni
Aug 14, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Krishnansu S Tewari, Bradley J Monk
Jan 21, 2021·Expert Review of Anticancer Therapy·Christine GennigensGuy Jerusalem
Jun 23, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Gustavo Arruda VianiJuliana Fernandes Pavoni
Mar 7, 2020·The Lancet Oncology·Henrike WesterveldRemi A Nout
Feb 27, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Maura CampitelliCynthia Aristei
May 1, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Yvette SeppenwooldeDietmar Georg
May 4, 2021·Clinical Case Reports·Olga P MatylevichSiarhei A Mavrichev
May 15, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·D C R Fernandes, H J N Andreyev
Jun 3, 2021·Journal of Personalized Medicine·François LuciaUlrike Schick
Jun 2, 2021·Gynecologic Oncology·Melica Nourmoussavi BrodeurMaroie Barkati
Jul 17, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·C W WilliamsonL K Mell
Aug 4, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hanbo ChenSuresh Senan
Nov 11, 2021·Deutsches Ärzteblatt International·Matthias W BeckmannTanja Fehm

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